ethyl loflazepate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 1092 29177-84-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ethyl flucozepate
  • CM 6912
  • ethyl loflazepate
  • meilax
  • victan
  • CM6912
  • CM-6912
  • Molecular weight: 360.77
  • Formula: C18H14ClFN2O3
  • CLOGP: 3.19
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 67.76
  • ALOGS: -4.84
  • ROTB: 4

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Altered state of consciousness 52.10 29.39 18 932 25212 63462860
Tongue oedema 50.11 29.39 12 938 4574 63483498
Rash maculo-papular 33.88 29.39 14 936 31882 63456190
Neuroleptic malignant syndrome 30.38 29.39 10 940 12046 63476026

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Altered state of consciousness 57.18 26.31 24 1524 43798 79699042
Tongue oedema 41.76 26.31 12 1536 7105 79735735
Parkinsonism 39.20 26.31 14 1534 16570 79726270
Irritability 35.87 26.31 17 1531 41127 79701713
Neuroleptic malignant syndrome 35.61 26.31 15 1533 27544 79715296
Suicide attempt 34.67 26.31 21 1527 82911 79659929
Mallory-Weiss syndrome 31.86 26.31 8 1540 2844 79739996
Intentional overdose 29.96 26.31 21 1527 105939 79636901
Patient isolation 28.13 26.31 4 1544 63 79742777
Pressure of speech 27.21 26.31 6 1542 1222 79741618
Hepatic function abnormal 26.71 26.31 17 1531 73090 79669750

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA18 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Anxiety indication 48694002
Myasthenia gravis contraindication 91637004 DOID:437
Angle-closure glaucoma contraindication 392291006 DOID:13550




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.28 acidic
pKa2 9.89 acidic
pKa3 3.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01293 KEGG_DRUG
C0059772 UMLSCUI
CHEBI:31573 CHEBI
CHEMBL1213460 ChEMBL_ID
DB01545 DRUGBANK_ID
C029617 MESH_SUPPLEMENTAL_RECORD_UI
3299 PUBCHEM_CID
C040581 MESH_SUPPLEMENTAL_RECORD_UI
4837 INN_ID
VJB5FW9W9J UNII
24524 RXNORM
005857 NDDF
769093001 SNOMEDCT_US
C0099755 UMLSCUI
71735-10-9 SECONDARY_CAS_RN
155667 PUBCHEM_CID
Y3R871DUQ5 UNII

Pharmaceutical products:

None