alcuronium indications/contra

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 109 23214-96-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alcuronium
  • diallylnortoxiferine
  • diallyltoxiferine
  • alcuronium chloride
  • alnortoxiferine
  • allnortoxiferine
  • dialferine
  • alcuronium dichloride
A non-depolarizing skeletal muscle relaxant similar to TUBOCURARINE. It is used as an anesthesia adjuvant.
  • Molecular weight: 666.91
  • Formula: C44H50N4O2
  • CLOGP: -3.49
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 2
  • TPSA: 46.94
  • ALOGS: -6.48
  • ROTB: 6

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1963 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC M03AA01 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Curare alkaloids
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018733 Nicotinic Antagonists
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.87 acidic
pKa2 8.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M2 GPCR ALLOSTERIC MODULATOR Kd 6.90 IUPHAR
Muscarinic acetylcholine receptor M3 GPCR ALLOSTERIC MODULATOR Kd 5.80 IUPHAR
Muscarinic acetylcholine receptor M1 GPCR ALLOSTERIC MODULATOR Kd 5 IUPHAR
Neuronal acetylcholine receptor; alpha4/beta4 Ion channel IC50 4.35 WOMBAT-PK
Acetylcholine receptor Ion channel WOMBAT-PK
Neuronal acetylcholine receptor subunit alpha-2 Ion channel Ki 4.72 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 5.60 WOMBAT-PK
Neuronal acetylcholine receptor subunit alpha-7 Ion channel Ki 5.96 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR EC50 8.70 CHEMBL

External reference:

scroll-->
IDSource
341 IUPHAR_LIGAND_ID
N0000166958 NUI
C0001981 UMLSCUI
D01215 KEGG_DRUG
490DW6501Y UNII
2166 INN_ID
15180-03-7 SECONDARY_CAS_RN
460 RXNORM
350063006 SNOMEDCT_US
395958004 SNOMEDCT_US
N0000166958 NDFRT
004815 NDDF
CHEMBL120476 ChEMBL_ID
CHEMBL1180293 ChEMBL_ID
21158560 PUBCHEM_CID
D000443 MESH_DESCRIPTOR_UI
CHEBI:31185 CHEBI

Pharmaceutical products:

None