ethisterone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1084 434-03-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ethisterone
  • aethisteron
  • anhydrohydroxyprogesterone
  • anhydroxyprogesterone
  • ethinone
  • ethinyltestosterone
  • ethynyltestosterone
  • nugestoral
  • pregneninolone
  • progestoral
17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.
  • Molecular weight: 312.45
  • Formula: C21H28O2
  • CLOGP: 3.31
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -4.54
  • ROTB: 0

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03DC04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Estren derivatives
ATC G03FA03 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:59826 progestins

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor Ki 7.02 DRUG MATRIX
Sex hormone-binding globulin Secreted Kd 8.78 CHEMBL
Androgen receptor Transcription factor Ki 7.36 DRUG MATRIX
Progesterone receptor Transcription factor Ki 8.11 DRUG MATRIX
Polyphenol oxidase 2 Enzyme IC50 5.58 CHEMBL

External reference:

IDSource
N0000167418 NUI
C0015025 UMLSCUI
CHEBI:34749 CHEBI
CHEMBL241694 ChEMBL_ID
D005003 MESH_DESCRIPTOR_UI
5284557 PUBCHEM_CID
374 INN_ID
P201BVY1MJ UNII
4129 RXNORM
001302 NDDF
126094004 SNOMEDCT_US
28841002 SNOMEDCT_US

Pharmaceutical products:

None