estramustine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives | 1065 | 2998-57-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.00 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Osteonecrosis of jaw | 40.66 | 38.12 | 10 | 119 | 17879 | 34938923 |
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01XX11 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents |
| FDA CS | M0007772 | Estradiol |
| FDA CS | M0014901 | Nitrogen Mustard Compounds |
| FDA MoA | N0000000236 | Alkylating Activity |
| FDA EPC | N0000175558 | Alkylating Drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:66987 | radiation protective drugs |
| MeSH PA | D000477 | Alkylating Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018906 | Antineoplastic Agents, Alkylating |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D009676 | Noxae |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Neoplasm of prostate | indication | 126906006 | DOID:10283 |
| Gynecomastia | contraindication | 4754008 | DOID:12698 |
| Hypocalcemia | contraindication | 5291005 | |
| Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Migraine | contraindication | 37796009 | DOID:6364 |
| Immunosuppression | contraindication | 38013005 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Body fluid retention | contraindication | 43498006 | |
| Chronic heart failure | contraindication | 48447003 | |
| Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
| Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Edema | contraindication | 267038008 | |
| Pregnancy, function | contraindication | 289908002 | |
| Bone marrow depression | contraindication | 307762000 | |
| Thromboembolic disorder | contraindication | 371039008 | |
| Impotence | contraindication | 397803000 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Hypercalcemia associated with Metabolic Bone Disease | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4022118 | VUID |
| N0000020124 | NUI |
| D04066 | KEGG_DRUG |
| 4022118 | VANDF |
| C0014921 | UMLSCUI |
| CHEBI:4868 | CHEBI |
| CHEMBL1575 | ChEMBL_ID |
| D004961 | MESH_DESCRIPTOR_UI |
| DB01196 | DRUGBANK_ID |
| 9076 | IUPHAR_LIGAND_ID |
| 2877 | INN_ID |
| 35LT29625A | UNII |
| 259331 | PUBCHEM_CID |
| 4089 | RXNORM |
| d01351 | MMSL |
| 004824 | NDDF |
| 108768000 | SNOMEDCT_US |
| 386909008 | SNOMEDCT_US |
Pharmaceutical products:
None