estradiol dipropionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
estrogens 1060 113-38-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • estradiol dipropionate
  • dimenformon dipropionate
  • estradiol propionate
  • Molecular weight: 384.52
  • Formula: C24H32O4
  • CLOGP: 5.80
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 52.60
  • ALOGS: -6.36
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 5 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP2K6,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PRKDC,STK33,TEK,TGFBR1 27
kinase-selectivity-class EIF2AK3,GRK2 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0447348 Estradiol Congeners
FDA MoA N0000000100 Estrogen Receptor Agonists
MeSH PA D004967 Estrogens
MeSH PA D006728 Hormones
FDA EPC N0000175825 Estrogen
CHEBI has role CHEBI:50114 estrogen
CHEBI has role CHEBI:77746 human metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01617 KEGG_DRUG
4017609 VANDF
4021205 VANDF
C0059618 UMLSCUI
CHEBI:31560 CHEBI
EST PDB_CHEM_ID
CHEMBL1697791 ChEMBL_ID
CHEMBL2356687 ChEMBL_ID
C023482 MESH_SUPPLEMENTAL_RECORD_UI
8225 PUBCHEM_CID
NIG5418BXB UNII
DB00783 DRUGBANK_ID
4083 RXNORM
4684 MMSL
6157 MMSL
73244 MMSL
8602 MMSL
d00537 MMSL
001265 NDDF
001267 NDDF
126172005 SNOMEDCT_US
12839006 SNOMEDCT_US
C0014912 UMLSCUI
5757 PUBCHEM_CID
406 INN_ID
D004958 MESH_DESCRIPTOR_UI
CHEBI:16469 CHEBI
NIG5418BXB INXIGHT DRUGS

Pharmaceutical products:

None