albendazole sulfoxide indications/contra

Stem definitionDrug idCAS RN
anthelminthics, tiabendazole derivatives 104 54029-12-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • albendazole sulfoxide
  • albendazole oxide
  • rycobendazole
  • Molecular weight: 281.33
  • Formula: C12H15N3O3S
  • CLOGP: 1.70
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 84.08
  • ALOGS: -2.50
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1982 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000923 Anticestodal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000980 Antiplatyhelmintic Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.01 acidic
pKa2 3.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tubulin alpha chain Structural WOMBAT-PK

External reference:

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IDSource
D07106 KEGG_DRUG
83969 PUBCHEM_CID
CHEBI:16959 CHEBI
CHEMBL1665 ChEMBL_ID
C027186 MESH_SUPPLEMENTAL_RECORD_UI
J39B52TV34 UNII
5979 INN_ID
DB13871 DRUGBANK_ID

Pharmaceutical products:

None