albendazole indications/contra

Stem definitionDrug idCAS RN
anthelminthics, tiabendazole derivatives 103 54965-21-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • albendazole
  • albamelin
  • albendol
  • albenza
A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
  • Molecular weight: 265.33
  • Formula: C12H15N3O2S
  • CLOGP: 3.46
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 67.01
  • ALOGS: -4.07
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.40 g O

Approvals:

DateAgencyCompanyOrphan
June 11, 1996 FDA AMEDRA PHARMS

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Vomiting 193.51 49.71 63 246 89468 3296082
Asthenia 131.55 49.71 44 265 65621 3319929
Pyrexia 107.31 49.71 40 269 81075 3304475
Gastritis 100.00 49.71 22 287 6555 3378995
Headache 95.27 49.71 38 271 91942 3293608
Conjunctival haemorrhage 74.48 49.71 13 296 1156 3384394
Gastroenteritis 74.26 49.71 16 293 4285 3381265
Diarrhoea 67.50 49.71 31 278 104317 3281233
Somnolence 65.38 49.71 22 287 32182 3353368
Dehydration 64.43 49.71 22 287 33627 3351923
Stevens-Johnson syndrome 61.86 49.71 15 294 6757 3378793
Dizziness 59.76 49.71 26 283 76486 3309064
Strongyloidiasis 58.74 49.71 9 300 353 3385197
Sedation 58.20 49.71 14 295 6087 3379463
Abdominal pain 57.61 49.71 22 287 46203 3339347
Loss of consciousness 56.15 49.71 19 290 28128 3357422
Encephalopathy 55.40 49.71 14 295 7448 3378102

Pharmacologic Action:

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SourceCodeDescription
ATC P02CA03 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Benzimidazole derivatives
FDA EPC N0000175481 Antihelminthic
MeSH PA D000871 Anthelmintics
CHEBI has role CHEBI:35443 anthelminthic drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000923 Anticestodal Agents
MeSH PA D050256 Antimitotic Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000980 Antiplatyhelmintic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D050258 Mitosis Modulators
FDA MoA N0000191624 Cytochrome P450 1A Inducers
MeSH PA D050257 Tubulin Modulators

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Echinococcus granulosus infection of liver indication 20790006
Echinococcus granulosus infection indication 75006000 DOID:1495
Echinococcus granulosus infection of lung indication 75388006
Cerebral cysticercosis indication 230215006
Echinococcus Granulosus Infection of the Peritoneum indication
Immunosuppression contraindication 38013005
Pancytopenia contraindication 127034005 DOID:12450
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.03 acidic
pKa2 4.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tubulin Structural INHIBITOR CHEMBL CHEMBL
Tubulin Structural INHIBITOR CHEMBL CHEMBL
Tubulin alpha chain Structural WOMBAT-PK

External reference:

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IDSource
DB00518 DRUGBANK_ID
4020995 VUID
N0000148464 NUI
C0001911 UMLSCUI
D00134 KEGG_DRUG
2082 PUBCHEM_CID
430 RXNORM
387558006 SNOMEDCT_US
96119002 SNOMEDCT_US
4141 MMSL
d03806 MMSL
4020995 VANDF
72826 MMSL
N0000148464 NDFRT
N0000006466 NDFRT
004079 NDDF
CHEMBL1483 ChEMBL_ID
CHEBI:16664 CHEBI
F4216019LN UNII
3967 INN_ID
D015766 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
ALBENZA HUMAN PRESCRIPTION DRUG LABEL 1 52054-550 TABLET, FILM COATED 200 mg ORAL NDA 15 sections
ALBENZA HUMAN PRESCRIPTION DRUG LABEL 1 55695-021 TABLET, FILM COATED 200 mg ORAL NDA 15 sections
ALBENZA HUMAN PRESCRIPTION DRUG LABEL 1 64896-693 TABLET, FILM COATED 200 mg ORAL NDA 15 sections
ALBENZA HUMAN PRESCRIPTION DRUG LABEL 1 65084-462 TABLET, FILM COATED 200 mg ORAL NDA 15 sections
ALBENZA HUMAN PRESCRIPTION DRUG LABEL 1 76413-145 TABLET, FILM COATED 200 mg ORAL NDA 15 sections