epinephrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 1028 51-43-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • epinephrine
  • vasoconstrictine
  • nephridine
  • renoform
  • suprarenin
  • epinephrine bitartrate
  • (-)-adrenaline
  • epinephrine hydrochloride
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
  • Molecular weight: 183.21
  • Formula: C9H13NO3
  • CLOGP: -0.68
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -0.99
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 mg P
2.24 mg Inhal.aerosol
20 mg Inhal.solution

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.09 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 3 %
S (Water solubility) 0.18 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.69

Approvals:

DateAgencyCompanyOrphan
Nov. 19, 1948 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 983.90 9.23 335 172438 3165 90452509
Hereditary angioedema 827.91 9.23 389 172384 8976 90446698
Anaphylactic reaction 761.62 9.23 886 171887 86638 90369036
Stress cardiomyopathy 686.55 9.23 385 172388 12970 90442704
Pemphigus 545.97 9.23 17 172756 326847 90128827
Device failure 505.50 9.23 252 172521 6645 90449029
Hand deformity 496.43 9.23 15 172758 296347 90159327
Glossodynia 487.91 9.23 32 172741 321747 90133927
Sinusitis 478.10 9.23 1589 171184 341499 90114175
Synovitis 473.99 9.23 42 172731 329710 90125964
Anaphylactic shock 469.68 9.23 427 172346 31190 90424484
Contraindicated product administered 459.53 9.23 41 172732 320098 90135576
Cardiac arrest 440.74 9.23 749 172024 104186 90351488
Systemic lupus erythematosus 417.65 9.23 90 172683 361806 90093868
Anti-cyclic citrullinated peptide antibody positive 411.05 9.23 8 172765 236425 90219249
Maternal exposure during delivery 397.15 9.23 178 172595 3668 90452006
Pericarditis 392.01 9.23 33 172740 270118 90185556
Hepatic enzyme increased 390.14 9.23 103 172670 360633 90095041
Duodenal ulcer perforation 386.67 9.23 7 172766 221281 90234393
Infusion site pain 379.47 9.23 309 172464 19429 90436245
Joint swelling 378.78 9.23 247 172526 503053 89952621
Kounis syndrome 372.58 9.23 151 172622 2402 90453272
Arthropathy 362.59 9.23 123 172650 366119 90089555
Wound 354.34 9.23 73 172700 302907 90152767
Toxic anterior segment syndrome 341.89 9.23 137 172636 2113 90453561
Helicobacter infection 336.68 9.23 25 172748 226825 90228849
Anaesthetic complication 336.55 9.23 139 172634 2326 90453348
Drug intolerance 326.84 9.23 227 172546 447364 90008310
Infusion site swelling 321.75 9.23 227 172546 11493 90444181
Folliculitis 316.63 9.23 18 172755 204335 90251339
Hypotension 312.32 9.23 1338 171435 324059 90131615
Alopecia 309.30 9.23 293 172480 494778 89960896
General physical health deterioration 279.82 9.23 165 172608 354950 90100724
Infusion site erythema 279.75 9.23 222 172551 13448 90442226
Rheumatoid factor positive 279.20 9.23 11 172762 171639 90284035
Muscle injury 269.30 9.23 17 172756 176637 90279037
Rheumatic fever 259.03 9.23 7 172766 153114 90302560
Impaired healing 258.58 9.23 64 172709 234135 90221539
Accidental exposure to product 253.07 9.23 356 172417 42010 90413664
Psoriatic arthropathy 250.93 9.23 63 172710 228272 90227402
Impaired quality of life 241.89 9.23 258 172515 22886 90432788
Bronchitis 232.14 9.23 730 172043 152197 90303477
Abdominal discomfort 229.35 9.23 347 172426 476981 89978693
Illness 224.30 9.23 488 172285 81481 90374193
Infusion site pruritus 218.81 9.23 145 172628 6620 90449054
Insurance issue 217.92 9.23 175 172598 10783 90444891
Therapeutic product effect decreased 211.57 9.23 134 172639 277437 90178237
Liver injury 207.99 9.23 37 172736 170530 90285144
Infusion site extravasation 207.65 9.23 166 172607 10162 90445512
Type 2 diabetes mellitus 206.72 9.23 65 172708 203179 90252495
Rheumatoid arthritis 206.60 9.23 232 172541 362382 90093292
Bradycardia 204.65 9.23 477 172296 83370 90372304
Sleep disorder due to general medical condition, insomnia type 200.35 9.23 11 172762 128683 90326991
Chondrolysis 198.25 9.23 53 172720 192 90455482
Irritable bowel syndrome 197.75 9.23 74 172699 207374 90248300
Mobility decreased 193.90 9.23 119 172654 250615 90205059
Lower respiratory tract infection 192.41 9.23 120 172653 250539 90205135
Pulseless electrical activity 184.79 9.23 146 172627 8786 90446888
COVID-19 183.61 9.23 722 172051 168121 90287553
C-reactive protein abnormal 183.56 9.23 16 172757 127413 90328261
Swollen joint count increased 174.69 9.23 9 172764 111197 90344477
Ventricular tachycardia 174.04 9.23 225 172548 24483 90431191
Treatment failure 171.39 9.23 196 172577 303732 90151942
Stomatitis 169.65 9.23 164 172609 274534 90181140
Infusion site haemorrhage 167.84 9.23 113 172660 5298 90450376
Methaemoglobinaemia 164.67 9.23 100 172673 3915 90451759
Facet joint syndrome 164.54 9.23 5 172768 98384 90357290
Product dose omission issue 160.40 9.23 1028 171745 290659 90165015
Musculoskeletal stiffness 158.93 9.23 199 172574 296333 90159341
Blood cholesterol increased 156.30 9.23 102 172671 207910 90247764
Upper respiratory tract infection 156.26 9.23 569 172204 127749 90327925
Blister 155.42 9.23 154 172619 254844 90200830
Lip dry 150.07 9.23 11 172762 100944 90354730
Liquid product physical issue 148.22 9.23 68 172705 1482 90454192
Bronchospasm 148.08 9.23 190 172583 20519 90435155
Infusion site bruising 146.97 9.23 96 172677 4276 90451398
Generalised tonic-clonic seizure 146.23 9.23 249 172524 34654 90421020
Cardiogenic shock 145.21 9.23 205 172568 24263 90431411
Inappropriate schedule of product administration 141.61 9.23 614 172159 149319 90306355
Drug ineffective 132.92 9.23 3512 169261 1380786 89074888
Tachycardia 132.67 9.23 624 172149 157049 90298625
Ill-defined disorder 129.22 9.23 98 172675 184793 90270881
Dermatitis atopic 128.11 9.23 189 172584 23283 90432391
Inflammation 126.96 9.23 93 172680 178499 90277175
Completed suicide 123.47 9.23 61 172712 144997 90310677
Confusional state 123.45 9.23 354 172419 385851 90069823
Seasonal allergy 119.62 9.23 181 172592 22802 90432872
Peripheral venous disease 119.60 9.23 11 172762 83910 90371764
Ventricular fibrillation 116.75 9.23 139 172634 13905 90441769
Lagophthalmos 116.49 9.23 41 172732 431 90455243
Bursitis 115.68 9.23 53 172720 131601 90324073
Grip strength decreased 113.01 9.23 20 172753 92556 90363118
Respiratory tract infection 112.59 9.23 306 172467 58772 90396902
Swelling 112.52 9.23 415 172358 418643 90037031
Seizure 111.99 9.23 581 172192 152048 90303626
No adverse event 110.03 9.23 332 172441 67650 90388024
Gait inability 109.75 9.23 72 172701 146384 90309290
Fear 107.24 9.23 145 172628 16477 90439197
Headache 106.95 9.23 2269 170504 860477 89595197
Corneal oedema 106.46 9.23 58 172715 1843 90453831
Osteoarthritis 105.18 9.23 131 172642 195599 90260075
Asthma 104.60 9.23 805 171968 241355 90214319
Deep vein thrombosis postoperative 104.43 9.23 8 172765 70801 90384873
Fibromyalgia 103.75 9.23 145 172628 206124 90249550
Incorrect drug administration rate 102.98 9.23 83 172690 5140 90450534
Hypercholesterolaemia 101.24 9.23 33 172740 100859 90354815
Joint range of motion decreased 101.21 9.23 67 172706 135576 90320098
Drug ineffective for unapproved indication 100.91 9.23 318 172455 66326 90389348
Urinary tract infection 98.95 9.23 953 171820 304679 90150995
Stridor 98.41 9.23 78 172695 4715 90450959
Infusion site mass 96.20 9.23 57 172716 2132 90453542
Prescribed underdose 94.24 9.23 15 172758 75004 90380670
Endophthalmitis 93.54 9.23 75 172698 4610 90451064
Pulmonary fibrosis 93.32 9.23 44 172729 107459 90348215
Stress 93.26 9.23 354 172419 81041 90374633
Administration site swelling 93.11 9.23 49 172724 1450 90454224
Dislocation of vertebra 93.01 9.23 3 172770 55965 90399709
Pulse absent 92.30 9.23 83 172690 5972 90449702
Liver disorder 91.70 9.23 59 172714 121210 90334464
Musculoskeletal pain 91.61 9.23 115 172658 171136 90284538
Shock 91.16 9.23 182 172591 28596 90427078
Poor venous access 90.78 9.23 146 172627 19381 90436293
C-reactive protein increased 90.73 9.23 128 172645 181261 90274413
Angioedema 90.49 9.23 301 172472 64575 90391099
Infusion site nodule 89.43 9.23 50 172723 1673 90454001
Discomfort 87.21 9.23 252 172521 274083 90181591
Injection site ischaemia 86.74 9.23 17 172756 3 90455671
Ear infection 86.24 9.23 311 172462 69464 90386210
Wound infection 85.73 9.23 48 172725 106354 90349320
Urticaria 84.99 9.23 941 171832 311793 90143881
Adjustment disorder with depressed mood 84.87 9.23 6 172767 56747 90398927
Arthralgia 83.38 9.23 1017 171756 777505 89678169
Arteriospasm coronary 82.51 9.23 72 172701 4978 90450696
Anaesthetic complication neurological 81.99 9.23 36 172737 705 90454969
Lip swelling 81.73 9.23 208 172565 38402 90417272
Expired product administered 81.01 9.23 82 172691 6840 90448834
Emotional distress 80.21 9.23 200 172573 36462 90419212
Anhedonia 78.79 9.23 103 172670 11328 90444346
Haemodynamic instability 78.17 9.23 104 172669 11635 90444039
Injury associated with device 77.71 9.23 66 172707 4398 90451276
Electrocardiogram ST segment elevation 77.45 9.23 63 172710 3953 90451721
Gastrointestinal disorder 77.12 9.23 242 172531 256445 90199229
Procedural hypotension 76.49 9.23 44 172729 1556 90454118
Renal injury 76.43 9.23 96 172677 10147 90445527
Adverse event 76.10 9.23 67 172706 117351 90338323
Sinus tachycardia 75.96 9.23 168 172605 28345 90427329
Needle issue 75.75 9.23 112 172661 13822 90441852
Vitamin B1 decreased 75.70 9.23 31 172742 507 90455167
Bone erosion 75.41 9.23 7 172766 53014 90402660
Knee arthroplasty 75.41 9.23 32 172741 83150 90372524
Left ventricle outflow tract obstruction 75.11 9.23 29 172744 403 90455271
Staphylococcal infection 75.05 9.23 233 172540 48206 90407468
Chills 74.81 9.23 469 172304 131512 90324162
Circulatory collapse 74.72 9.23 154 172619 24750 90430924
Infusion related reaction 74.45 9.23 477 172296 416303 90039371
Abdominal pain upper 74.03 9.23 354 172419 332320 90123354
Infusion site urticaria 73.66 9.23 44 172729 1671 90454003
Product quality issue 73.43 9.23 323 172450 79002 90376672
Hip arthroplasty 72.89 9.23 27 172746 76181 90379493
Sulphaemoglobinaemia 72.58 9.23 30 172743 503 90455171
Dermatitis contact 72.08 9.23 108 172665 13487 90442187
Cauda equina syndrome 71.85 9.23 40 172733 1327 90454347
Blood lactic acid decreased 70.94 9.23 28 172745 414 90455260
Night sweats 70.41 9.23 85 172688 128681 90326993
Infusion site rash 70.26 9.23 49 172724 2434 90453240
Loss of consciousness 69.57 9.23 482 172291 139756 90315918
Pharyngeal swelling 69.16 9.23 90 172683 9854 90445820
Accidental overdose 69.11 9.23 161 172612 28112 90427562
Cardiac output increased 69.00 9.23 29 172744 508 90455166
Incorrect route of product administration 68.92 9.23 233 172540 50393 90405281
Obesity 68.62 9.23 60 172713 105447 90350227
Administration site pain 68.60 9.23 37 172736 1152 90454522
Influenza 68.11 9.23 477 172296 138787 90316887
Injection site pallor 67.81 9.23 18 172755 63 90455611
Blepharospasm 67.62 9.23 12 172761 55433 90400241
Injection site pain 67.10 9.23 563 172210 173136 90282538
Vasoplegia syndrome 66.98 9.23 50 172723 2764 90452910
Toxicity to various agents 66.64 9.23 840 171933 287006 90168668
Chest discomfort 66.55 9.23 472 172301 137893 90317781
Unevaluable event 66.54 9.23 243 172530 54605 90401069
Unresponsive to stimuli 66.28 9.23 191 172582 37930 90417744
Peripheral ischaemia 66.08 9.23 67 172706 5600 90450074
Peripheral swelling 65.77 9.23 489 172284 412617 90043057
Wrong product administered 65.59 9.23 77 172696 7588 90448086
Drug-induced liver injury 65.51 9.23 46 172727 90272 90365402
Nail disorder 65.41 9.23 16 172757 59051 90396623
Heart rate increased 65.10 9.23 403 172370 112499 90343175
Body tinea 64.58 9.23 44 172729 2104 90453570
Electrocardiogram ST segment depression 64.09 9.23 52 172721 3251 90452423
Lupus vulgaris 63.95 9.23 6 172767 45053 90410621
Cough 63.89 9.23 1023 171750 367939 90087735
Neutropenia 63.43 9.23 218 172555 224686 90230988
Blood pressure decreased 63.38 9.23 297 172476 74598 90381076
Onychomadesis 63.01 9.23 7 172766 45991 90409683
Phrenic nerve paralysis 62.65 9.23 24 172749 326 90455348
Infusion site discharge 61.87 9.23 45 172728 2390 90453284
Product use issue 61.78 9.23 372 172401 329547 90126127
Hepatic cirrhosis 61.18 9.23 22 172751 63231 90392443
Post procedural complication 61.00 9.23 121 172652 18921 90436753
Systemic toxicity 60.66 9.23 22 172751 254 90455420
Decreased appetite 60.27 9.23 445 172328 376095 90079579
Lung disorder 59.99 9.23 122 172651 149761 90305913
Hypoaesthesia oral 59.75 9.23 107 172666 15493 90440181
Infusion site irritation 58.86 9.23 35 172738 1318 90454356
Airway peak pressure increased 58.52 9.23 24 172749 394 90455280
Pulmonary oedema 58.38 9.23 254 172519 61826 90393848
Hyperaesthesia 58.14 9.23 86 172687 10616 90445058
Sciatica 57.49 9.23 65 172708 101317 90354357
Ventricular hypokinesia 56.61 9.23 60 172713 5281 90450393
Apnoea 56.04 9.23 79 172694 9335 90446339
Autoimmune disorder 55.77 9.23 39 172734 76705 90378969
Breast cancer stage II 55.04 9.23 3 172770 35331 90420343
Tryptase increased 54.61 9.23 25 172748 542 90455132
Diarrhoea 54.55 9.23 1369 171404 937821 89517853
Lower limb fracture 54.49 9.23 49 172724 84964 90370710
Dry mouth 54.23 9.23 175 172598 183884 90271790
Hypoxia 54.04 9.23 277 172496 72122 90383552
Hyperlactacidaemia 53.98 9.23 52 172721 4084 90451590
Mydriasis 53.74 9.23 100 172673 14912 90440762
Tracheal deviation 53.29 9.23 20 172753 256 90455418
Meningitis aseptic 52.98 9.23 65 172708 6708 90448966
Retinitis 52.31 9.23 6 172767 38452 90417222
Epilepsy 51.96 9.23 48 172725 82158 90373516
Myocardial ischaemia 51.95 9.23 94 172679 13720 90441954
Swollen tongue 51.91 9.23 199 172574 45757 90409917
Multiple allergies 51.87 9.23 99 172674 15047 90440627
Administration site erythema 51.64 9.23 28 172745 881 90454793
Throat tightness 51.52 9.23 148 172625 29336 90426338
Hypopyon 51.50 9.23 28 172745 886 90454788
Fungal infection 50.90 9.23 188 172585 42473 90413201
Asthenia 50.87 9.23 714 172059 533037 89922637
Red blood cell sedimentation rate increased 50.14 9.23 50 172723 82545 90373129
Inhibitory drug interaction 49.48 9.23 44 172729 3119 90452555
Infusion site discomfort 49.44 9.23 35 172738 1781 90453893
Sleep disorder 49.29 9.23 202 172571 197828 90257846
Product distribution issue 49.15 9.23 47 172726 3658 90452016
Laryngeal oedema 48.98 9.23 63 172710 6818 90448856
Embolia cutis medicamentosa 48.61 9.23 24 172749 619 90455055
Oropharyngeal pain 48.61 9.23 381 172392 114806 90340868
Paraplegia 48.55 9.23 45 172728 3367 90452307
Erythema 48.02 9.23 657 172116 228589 90227085
Gastroenteritis viral 47.93 9.23 147 172626 30208 90425466
Kidney infection 47.15 9.23 132 172641 25784 90429890
Cyanosis 46.69 9.23 110 172663 19345 90436329
Cataract operation complication 46.62 9.23 16 172757 155 90455519
Liver function test increased 46.39 9.23 56 172717 84799 90370875
Vocal cord dysfunction 46.02 9.23 26 172747 888 90454786
Pharyngeal oedema 45.92 9.23 89 172684 13682 90441992
Thrombocytopenia 45.87 9.23 223 172550 208502 90247172
Vitamin B1 increased 45.82 9.23 16 172757 164 90455510
Metabolic acidosis 45.80 9.23 219 172554 55457 90400217
Prescribed overdose 45.77 9.23 72 172701 97553 90358121
Psoriasis 45.27 9.23 138 172635 147616 90308058
Infection susceptibility increased 45.02 9.23 46 172727 3880 90451794
C-reactive protein 44.99 9.23 4 172769 31363 90424311
Extradural abscess 44.73 9.23 29 172744 1275 90454399
Disease progression 44.69 9.23 151 172622 156464 90299210
Blood pressure increased 44.53 9.23 573 172200 196644 90259030
Pharyngitis streptococcal 44.52 9.23 84 172689 12658 90443016
Vasospasm 44.11 9.23 26 172747 963 90454711
Malignant neoplasm progression 42.75 9.23 87 172686 106783 90348891
Therapeutic product effect incomplete 42.70 9.23 207 172566 193689 90261985
Respiratory depression 41.75 9.23 92 172681 15483 90440191
Viral infection 41.69 9.23 173 172600 41241 90414433
Status asthmaticus 41.06 9.23 24 172749 875 90454799
Lupus-like syndrome 40.86 9.23 21 172752 48825 90406849
Coeliac disease 40.69 9.23 17 172756 44593 90411081
Foetal exposure during delivery 40.56 9.23 18 172755 362 90455312
Hepatitis 40.49 9.23 45 172728 70694 90384980
Status epilepticus 40.28 9.23 102 172671 18772 90436902
Eye infection 40.26 9.23 86 172687 14168 90441506
Respiratory distress 40.24 9.23 164 172609 38782 90416892
Blood lactic acid increased 39.94 9.23 65 172708 8713 90446961
Infusion site warmth 39.56 9.23 33 172740 2145 90453529
Condition aggravated 39.25 9.23 851 171922 594694 89860980
Acute kidney injury 39.10 9.23 406 172367 319981 90135693
Skin infection 38.60 9.23 97 172676 17767 90437907
Meningitis chemical 38.24 9.23 16 172757 277 90455397
Anxiety 38.24 9.23 815 171958 308957 90146717
Paranasal cyst 37.99 9.23 22 172751 788 90454886
Dyspepsia 37.82 9.23 222 172551 197938 90257736
Taste disorder 37.65 9.23 37 172736 61509 90394165
Multiple organ dysfunction syndrome 37.56 9.23 241 172532 68095 90387579
Cardiotoxicity 37.24 9.23 73 172700 11316 90444358
Mast cell activation syndrome 37.22 9.23 28 172745 1566 90454108
Troponin I increased 36.94 9.23 34 172739 2521 90453153
Purtscher retinopathy 36.91 9.23 13 172760 137 90455537
Oral herpes 36.91 9.23 144 172629 33380 90422294
Blood pH decreased 36.90 9.23 34 172739 2524 90453150
Paralysis 36.84 9.23 73 172700 11405 90444269
Vascular malformation 36.81 9.23 21 172752 731 90454943
Anaphylactoid reaction 36.77 9.23 44 172729 4424 90451250
Bundle branch block left 36.71 9.23 59 172714 7826 90447848
Intentional self-injury 36.54 9.23 6 172767 29328 90426346
Glucose tolerance impaired 36.16 9.23 59 172714 7926 90447748
Throat irritation 36.12 9.23 186 172587 48509 90407165
Type I hypersensitivity 35.99 9.23 42 172731 4113 90451561
Limb injury 35.22 9.23 136 172637 31372 90424302
Rhinitis 35.06 9.23 79 172694 13493 90442181
Extradural haematoma 34.83 9.23 30 172743 2038 90453636
Poor quality sleep 34.81 9.23 115 172658 24578 90431096
Cystitis 34.67 9.23 232 172541 66486 90389188
Anterior chamber cell 34.55 9.23 20 172753 716 90454958
Eczema 34.51 9.23 195 172578 52675 90402999
Foot deformity 34.08 9.23 38 172735 59613 90396061
Removal of foreign body 34.05 9.23 8 172765 14 90455660
Administration site pruritus 33.87 9.23 15 172758 300 90455374
Pancytopenia 33.60 9.23 117 172656 120146 90335528
Injection site coldness 33.27 9.23 11 172762 94 90455580
Walking aid user 33.25 9.23 13 172760 35493 90420181
Drug tolerance decreased 33.14 9.23 10 172763 32120 90423554
Cardio-respiratory arrest 33.07 9.23 220 172553 62920 90392754
Procedural complication 33.04 9.23 48 172725 5830 90449844
Memory impairment 33.02 9.23 230 172543 197014 90258660
Pneumocephalus 32.81 9.23 14 172759 255 90455419
Vitritis 32.57 9.23 26 172747 1588 90454086
Administration site reaction 32.36 9.23 15 172758 335 90455339
Oxygen saturation decreased 32.21 9.23 330 172443 107153 90348521
Tremor 32.06 9.23 439 172334 152734 90302940
Infusion site discolouration 32.01 9.23 22 172751 1067 90454607
Distributive shock 32 9.23 36 172737 3388 90452286
Nasal discharge discolouration 31.94 9.23 33 172740 2820 90452854
Product adhesion issue 31.87 9.23 44 172729 5098 90450576
Administration site extravasation 31.86 9.23 23 172750 1207 90454467
Peripheral nerve injury 31.84 9.23 19 172754 720 90454954
Amnesia 31.37 9.23 104 172669 108401 90347273
Onychomycosis 31.36 9.23 16 172757 37360 90418314
Injection site hypoaesthesia 31.03 9.23 18 172755 647 90455027
Leukopenia 30.89 9.23 94 172679 100616 90355058
Premature delivery 30.82 9.23 151 172622 38611 90417063
Ophthalmoplegia 30.74 9.23 26 172747 1723 90453951
Catheter site pain 30.55 9.23 45 172728 5534 90450140
PCO2 increased 30.52 9.23 23 172750 1290 90454384
Uterine hypertonus 30.44 9.23 14 172759 307 90455367
Platelet aggregation inhibition 30.43 9.23 12 172761 177 90455497
Influenza like illness 30.43 9.23 260 172513 80351 90375323
Respiratory acidosis 30.22 9.23 55 172718 8064 90447610
Electrocardiogram QRS complex prolonged 30.22 9.23 52 172721 7296 90448378
Device infusion issue 30.18 9.23 31 172742 2631 90453043
Joint stiffness 29.97 9.23 65 172708 77977 90377697
Impaired work ability 29.96 9.23 93 172680 19233 90436441
Hepatotoxicity 29.88 9.23 26 172747 45816 90409858
Bladder prolapse 29.85 9.23 28 172745 2127 90453547
Ventricular extrasystoles 29.74 9.23 73 172700 13177 90442497
Back injury 29.72 9.23 27 172746 46595 90409079
Tooth infection 29.39 9.23 95 172678 20075 90435599
Intentional product use issue 29.33 9.23 268 172505 216624 90239050
Abortion spontaneous 29.20 9.23 36 172737 54020 90401654
Road traffic accident 29.20 9.23 106 172667 107520 90348154
Exostosis 29.11 9.23 35 172738 53099 90402575
Product use in unapproved indication 29.05 9.23 843 171930 335393 90120281
Injection site injury 28.94 9.23 20 172753 979 90454695
Electrocardiogram abnormal 28.94 9.23 62 172711 10236 90445438
Product contamination microbial 28.78 9.23 13 172760 273 90455401
Post cholecystectomy syndrome 28.77 9.23 19 172754 862 90454812
Hyperthermia malignant 28.55 9.23 22 172751 1276 90454398
Nasal congestion 28.37 9.23 263 172510 83151 90372523
Product administration interrupted 28.22 9.23 69 172704 12423 90443251
Nerve root injury 28.19 9.23 9 172764 68 90455606
Drug reaction with eosinophilia and systemic symptoms 28.18 9.23 24 172749 42734 90412940
Spinal epidural haemorrhage 28.14 9.23 13 172760 288 90455386
Product colour issue 28.12 9.23 18 172755 774 90454900
Electrocardiogram ST segment abnormal 28.07 9.23 21 172752 1165 90454509
Hyponatraemia 28.00 9.23 145 172628 133393 90322281
Macular degeneration 27.98 9.23 19 172754 37951 90417723
Ischaemia 27.98 9.23 42 172731 5253 90450421
Loss of personal independence in daily activities 27.86 9.23 149 172624 135956 90319718
Finger deformity 27.73 9.23 14 172759 32883 90422791
Myelosuppression 27.60 9.23 37 172736 53554 90402120
Hypopnoea 27.59 9.23 38 172735 4393 90451281
Oedema peripheral 27.45 9.23 337 172436 257578 90198096
Sinus disorder 27.25 9.23 134 172639 34313 90421361
Device issue 27.12 9.23 120 172653 29417 90426257
Underdose 27.11 9.23 38 172735 53979 90401695
Infusion site induration 27.04 9.23 23 172750 1536 90454138
Cholestasis 26.97 9.23 18 172755 36281 90419393
Ventricular arrhythmia 26.82 9.23 37 172736 4284 90451390
Rectal prolapse 26.79 9.23 27 172746 2240 90453434
Hypersensitivity 26.75 9.23 661 172112 454016 90001658
Blood immunoglobulin A increased 26.60 9.23 21 172752 1262 90454412
Fear of eating 26.49 9.23 14 172759 418 90455256
Pallor 26.39 9.23 132 172641 34033 90421641
Injection site swelling 26.39 9.23 200 172573 59639 90396035
Anaphylactoid shock 26.31 9.23 14 172759 424 90455250
Eyelid ptosis 26.21 9.23 55 172718 8951 90446723
Tinnitus 26.19 9.23 156 172617 42946 90412728
Neuromuscular block prolonged 26.13 9.23 16 172757 636 90455038
Hypercapnia 25.83 9.23 46 172727 6631 90449043
Central pain syndrome 25.72 9.23 16 172757 654 90455020
Mastoiditis 25.67 9.23 23 172750 1647 90454027
Bursitis infective 25.62 9.23 22 172751 1488 90454186
Foetal heart rate decreased 25.45 9.23 11 172762 207 90455467
Mean arterial pressure decreased 25.45 9.23 11 172762 207 90455467
Injection site inflammation 25.40 9.23 37 172736 4504 90451170
Acute respiratory distress syndrome 25.18 9.23 115 172658 28571 90427103
Drug abuse 25.15 9.23 77 172696 82270 90373404
Administration site bruise 25.08 9.23 14 172759 467 90455207
Sinobronchitis 25.06 9.23 16 172757 685 90454989
Delirium 24.99 9.23 108 172665 104251 90351423
Retinal artery occlusion 24.94 9.23 26 172747 2245 90453429
Postural orthostatic tachycardia syndrome 24.93 9.23 26 172747 2246 90453428
Overdose 24.93 9.23 431 172342 157278 90298396
Infusion site infection 24.92 9.23 28 172745 2632 90453042
Gas gangrene 24.91 9.23 10 172763 155 90455519
Arterial spasm 24.88 9.23 8 172765 62 90455612
PO2 decreased 24.75 9.23 22 172751 1559 90454115
Infusion site scar 24.61 9.23 15 172758 591 90455083
Gait disturbance 24.57 9.23 349 172424 260147 90195527
Incorrect dose administered 24.45 9.23 244 172529 78686 90376988
Seronegative arthritis 24.41 9.23 3 172770 18231 90437443
Sensitive skin 24.14 9.23 31 172742 3350 90452324
Aqueous fibrin 24.06 9.23 9 172764 114 90455560
Muscle tightness 24.00 9.23 68 172705 13371 90442303
Flushing 23.86 9.23 266 172507 88225 90367449
Upper airway obstruction 23.81 9.23 18 172755 1014 90454660
Spinal epidural haematoma 23.79 9.23 20 172753 1314 90454360
Hypoaesthesia 23.65 9.23 439 172334 313771 90141903
Mental status changes 23.59 9.23 156 172617 44523 90411151
Schizencephaly 23.57 9.23 12 172761 331 90455343
Apnoeic attack 23.57 9.23 12 172761 331 90455343
Cerebral haemorrhage foetal 23.41 9.23 12 172761 336 90455338
Device expulsion 23.41 9.23 26 172747 40860 90414814
Oropharyngeal discomfort 23.40 9.23 48 172725 7687 90447987
Liver function test abnormal 23.36 9.23 38 172735 50807 90404867
Nephrolithiasis 23.32 9.23 167 172606 48918 90406756
Hyperlipidaemia 23.28 9.23 96 172677 22820 90432854
Product administration error 23.25 9.23 106 172667 26317 90429357
Frequent bowel movements 23.06 9.23 46 172727 56889 90398785
Neonatal toxicity 22.90 9.23 7 172766 45 90455629
Allergic sinusitis 22.86 9.23 24 172749 2089 90453585
Compartment syndrome 22.86 9.23 28 172745 2884 90452790
Oedema 22.74 9.23 258 172515 200037 90255637
Upper-airway cough syndrome 22.70 9.23 72 172701 15063 90440611
Burns second degree 22.34 9.23 23 172750 1957 90453717
Polyarthritis 22.31 9.23 4 172769 18346 90437328
Interstitial lung disease 22.25 9.23 73 172700 76332 90379342
Catarrh 22.19 9.23 21 172752 1613 90454061
Intentional overdose 22.17 9.23 275 172498 93559 90362115
Corneal epithelium defect 22.14 9.23 13 172760 478 90455196
Blood pressure abnormal 22.13 9.23 85 172688 19560 90436114
Electrocardiogram T wave inversion 22.06 9.23 31 172742 3652 90452022
Myopathy toxic 21.91 9.23 14 172759 600 90455074
Productive cough 21.86 9.23 234 172539 76829 90378845
Injection site erythema 21.71 9.23 285 172488 98217 90357457
Epidural haemorrhage 21.62 9.23 11 172762 303 90455371
Speech disorder 21.61 9.23 155 172618 45430 90410244
Harlequin syndrome 21.59 9.23 10 172763 223 90455451
Obstructive airways disorder 21.45 9.23 102 172671 25767 90429907
Orthostatic hypotension 21.41 9.23 29 172744 41798 90413876
Post-traumatic stress disorder 21.40 9.23 43 172730 6785 90448889
Spinal stroke 21.36 9.23 7 172766 58 90455616
Electric shock 21.26 9.23 21 172752 1701 90453973
Swelling face 21.23 9.23 243 172530 81109 90374565
Parophthalmia 21.21 9.23 12 172761 411 90455263
Osteonecrosis of jaw 21.17 9.23 26 172747 39077 90416597
Creatinine renal clearance decreased 21.16 9.23 5 172768 18894 90436780
Neurotoxicity 21.08 9.23 89 172684 21378 90434296
Brain injury 21.07 9.23 46 172727 7692 90447982
Administration site nodule 21.06 9.23 6 172767 29 90455645
Masked fever 21.06 9.23 4 172769 0 90455674
Injury 20.94 9.23 258 172515 197091 90258583
Product dose omission in error 20.91 9.23 86 172687 20417 90435257
Nystagmus 20.87 9.23 44 172729 7183 90448491
Weight increased 20.83 9.23 622 172151 417305 90038369
Extremity necrosis 20.77 9.23 22 172751 1935 90453739
Vitamin D increased 20.73 9.23 16 172757 930 90454744
Anal skin tags 20.61 9.23 14 172759 666 90455008
Pustular psoriasis 20.60 9.23 5 172768 18551 90437123
Bacterial infection 20.59 9.23 94 172679 23350 90432324
Respiratory tract congestion 20.54 9.23 105 172668 27305 90428369
Postresuscitation encephalopathy 20.53 9.23 5 172768 11 90455663
Spinal cord compression 20.52 9.23 35 172738 4876 90450798
Dyspnoea 20.47 9.23 1947 170826 879008 89576666
Administration site haemorrhage 20.47 9.23 7 172766 67 90455607
Laboratory test abnormal 20.45 9.23 30 172743 41824 90413850
Systolic anterior motion of mitral valve 20.42 9.23 6 172767 33 90455641
Device ineffective 20.40 9.23 10 172763 254 90455420
Supraventricular tachycardia 20.34 9.23 73 172700 16263 90439411
Inappropriate antidiuretic hormone secretion 20.24 9.23 6 172767 19499 90436175
Vitamin B12 increased 20.22 9.23 21 172752 1805 90453869
Septic arthritis staphylococcal 20.21 9.23 13 172760 564 90455110
Scar 20.20 9.23 70 172703 15325 90440349
Drug resistance 20.18 9.23 17 172756 30432 90425242
Anaemia 20.17 9.23 515 172258 352287 90103387
Diplegia 20.11 9.23 19 172754 1456 90454218
Trigemino-cardiac reflex 20.02 9.23 7 172766 72 90455602
Brain stem syndrome 19.82 9.23 14 172759 710 90454964
Vitamin D deficiency 19.80 9.23 76 172697 17480 90438194
Trigeminal palsy 19.77 9.23 7 172766 75 90455599
Nerve block 19.77 9.23 15 172758 850 90454824
Pregnancy 19.68 9.23 57 172716 61990 90393684
Otitis media 19.65 9.23 38 172735 5832 90449842
Infusion site oedema 19.62 9.23 17 172756 1164 90454510
Soft tissue atrophy 19.57 9.23 6 172767 39 90455635
Eye pruritus 19.56 9.23 108 172665 28919 90426755
Fear of death 19.55 9.23 17 172756 1170 90454504
Delayed recovery from anaesthesia 19.53 9.23 16 172757 1014 90454660
Systolic dysfunction 19.49 9.23 21 172752 1883 90453791
Granulocyte count increased 19.48 9.23 19 172754 1515 90454159
Aspartate aminotransferase 19.46 9.23 14 172759 731 90454943
Dactylitis 19.44 9.23 30 172743 3843 90451831
Paranasal sinus discomfort 19.34 9.23 39 172734 6171 90449503
Tooth abscess 19.30 9.23 72 172701 16341 90439333
Monoplegia 19.21 9.23 29 172744 3645 90452029
Metastases to liver 19.19 9.23 16 172757 28791 90426883
Spinal anaesthesia 19.13 9.23 7 172766 83 90455591
Lung hyperinflation 18.94 9.23 18 172755 1390 90454284
Medical device site cellulitis 18.78 9.23 9 172764 217 90455457
Depression 18.77 9.23 433 172340 300168 90155506
Laryngeal obstruction 18.76 9.23 7 172766 88 90455586
Temperature intolerance 18.75 9.23 58 172715 11972 90443702
Foetal death 18.73 9.23 8 172765 20715 90434959
Local reaction 18.63 9.23 14 172759 782 90454892
Dysphemia 18.63 9.23 26 172747 3044 90452630
Eyelid rash 18.62 9.23 11 172762 409 90455265
Axillary nerve injury 18.61 9.23 6 172767 47 90455627
Troponin T increased 18.58 9.23 19 172754 1604 90454070
Immunisation reaction 18.56 9.23 14 172759 786 90454888
Visual acuity reduced 18.47 9.23 91 172682 23319 90432355
Mastocytosis 18.44 9.23 15 172758 941 90454733
Arthropod bite 18.31 9.23 47 172726 8720 90446954
Infection 18.26 9.23 538 172235 361556 90094118
Palpitations 18.25 9.23 364 172409 136364 90319310
Hepatocellular injury 18.19 9.23 17 172756 28941 90426733
Acute respiratory failure 18.12 9.23 142 172631 42776 90412898
Inability to afford medication 18.11 9.23 28 172745 3594 90452080
Insomnia 17.95 9.23 491 172282 332983 90122691
Administration site mass 17.93 9.23 5 172768 22 90455652
Epidural analgesia 17.93 9.23 8 172765 163 90455511
Thrombosis 17.88 9.23 216 172557 73035 90382639
Dental restoration failure 17.83 9.23 16 172757 1148 90454526
Obstruction 17.79 9.23 29 172744 3892 90451782
Bradycardia foetal 17.76 9.23 12 172761 566 90455108
Procedure aborted 17.71 9.23 8 172765 168 90455506
Enzyme induction 17.68 9.23 6 172767 56 90455618
Vitamin B12 deficiency 17.61 9.23 42 172731 7444 90448230
Localised infection 17.61 9.23 117 172656 33445 90422229
Product contamination 17.59 9.23 16 172757 1168 90454506
Cellulitis 17.59 9.23 258 172515 91079 90364595
Injection site haemorrhage 17.53 9.23 103 172670 28215 90427459
Feeling abnormal 17.50 9.23 430 172343 166805 90288869
Immunodeficiency 17.45 9.23 35 172738 43199 90412475
Gastrooesophageal reflux disease 17.44 9.23 218 172555 166119 90289555
Spondylitis 17.44 9.23 3 172770 14175 90441499
Hypoventilation 17.38 9.23 34 172739 5262 90450412
Eye inflammation 17.35 9.23 43 172730 7808 90447866
Heart rate decreased 17.35 9.23 167 172606 53338 90402336
Vasoconstriction 17.31 9.23 14 172759 871 90454803
Meningitis 17.23 9.23 45 172728 8436 90447238
Rotator cuff syndrome 17.21 9.23 68 172705 15851 90439823
Disseminated intravascular coagulation 17.19 9.23 84 172689 21454 90434220
Streptococcal infection 17.10 9.23 41 172732 7292 90448382
Blood creatinine increased 17.07 9.23 118 172655 101268 90354406
Rheumatoid factor increased 17.05 9.23 22 172751 2389 90453285
Product measured potency issue 17.01 9.23 7 172766 116 90455558
Post procedural infection 16.90 9.23 53 172720 11021 90444653
Neuroleptic malignant syndrome 16.89 9.23 4 172769 15092 90440582
Rhinorrhoea 16.82 9.23 249 172524 88067 90367607
Tenderness 16.81 9.23 98 172675 26770 90428904
Administration site irritation 16.80 9.23 6 172767 66 90455608
Cold sweat 16.75 9.23 62 172711 14019 90441655
Respiratory failure 16.73 9.23 318 172455 118100 90337574
Arthritis bacterial 16.69 9.23 41 172732 7404 90448270
Cardiovascular insufficiency 16.68 9.23 18 172755 1617 90454057
Lactic acidosis 16.60 9.23 158 172615 50305 90405369
Hypoxic-ischaemic encephalopathy 16.59 9.23 31 172742 4637 90451037
Post-anoxic myoclonus 16.51 9.23 5 172768 31 90455643
Steroid dependence 16.51 9.23 21 172752 2248 90453426
Glomerular filtration rate increased 16.48 9.23 20 172753 2040 90453634
Tongue pruritus 16.48 9.23 13 172760 780 90454894
Pharyngitis 16.39 9.23 84 172689 21863 90433811
Eye irritation 16.37 9.23 116 172657 33862 90421812
Medical device site abscess 16.32 9.23 8 172765 203 90455471
Foetal heart rate abnormal 16.29 9.23 14 172759 948 90454726
Hepatic cytolysis 16.27 9.23 21 172752 30895 90424779
Inadequate analgesia 16.22 9.23 25 172748 3199 90452475
Maternal exposure during pregnancy 16.21 9.23 543 172230 359520 90096154
Joint noise 16.21 9.23 33 172740 5257 90450417
General symptom 16.19 9.23 4 172769 14664 90441010
Therapeutic product effect prolonged 16.18 9.23 10 172763 404 90455270
Corneal abrasion 16.15 9.23 16 172757 1300 90454374
Neuralgia 16.04 9.23 109 172664 31391 90424283
Therapeutic response shortened 16.01 9.23 86 172687 22793 90432881
Accidental exposure to product by child 15.98 9.23 16 172757 1317 90454357
Pupil fixed 15.96 9.23 20 172753 2108 90453566
Concussion 15.94 9.23 52 172721 11039 90444635
Cancer pain 15.92 9.23 28 172745 3997 90451677
Restrictive pulmonary disease 15.84 9.23 21 172752 2341 90453333
Akinesia 15.80 9.23 18 172755 1718 90453956
Retinal vasculitis 15.78 9.23 17 172756 1524 90454150
Injection site atrophy 15.77 9.23 13 172760 831 90454843
White blood cell count decreased 15.71 9.23 224 172549 166885 90288789
Hypertension 15.58 9.23 713 172060 456819 89998855
ECG signs of myocardial ischaemia 15.56 9.23 6 172767 83 90455591
Product preparation error 15.56 9.23 49 172724 10212 90445462
CSF pressure increased 15.45 9.23 7 172766 148 90455526
Product contamination physical 15.44 9.23 8 172765 229 90455445
Back pain 15.42 9.23 746 172027 316429 90139245
Procedural haemorrhage 15.41 9.23 24 172749 3100 90452574
Myocardial calcification 15.35 9.23 8 172765 232 90455442
Atonic urinary bladder 15.32 9.23 7 172766 151 90455523
Jaundice 15.22 9.23 24 172749 32493 90423181
Cranial nerve palsies multiple 15.18 9.23 6 172767 89 90455585
Genital erosion 15.16 9.23 10 172763 453 90455221
Laryngitis 15.12 9.23 48 172725 50705 90404969
Abdominal pain 15.07 9.23 609 172164 395112 90060562
Postpartum disorder 15.07 9.23 4 172769 14 90455660
Administration site rash 15.06 9.23 6 172767 91 90455583
Miosis 15.04 9.23 46 172727 9438 90446236
Product confusion 15.03 9.23 7 172766 158 90455516
Nervous system disorder 15.00 9.23 81 172692 21512 90434162
Administration site discolouration 14.99 9.23 5 172768 44 90455630
Genital ulceration 14.97 9.23 14 172759 1059 90454615
Nasal pruritus 14.96 9.23 12 172761 738 90454936
Anion gap increased 14.94 9.23 20 172753 2250 90453424
Sinus bradycardia 14.91 9.23 68 172705 16884 90438790
Neutropenic sepsis 14.86 9.23 8 172765 18122 90437552
Intervertebral discitis 14.81 9.23 29 172744 4491 90451183
Device malfunction 14.78 9.23 79 172694 20898 90434776
Glossoptosis 14.77 9.23 6 172767 96 90455578
Spinal cord infarction 14.76 9.23 9 172764 355 90455319
Product availability issue 14.75 9.23 39 172734 7365 90448309
Neuromuscular blockade 14.71 9.23 9 172764 357 90455317
Skin discolouration 14.70 9.23 139 172634 44176 90411498
Colitis ulcerative 14.65 9.23 62 172711 60204 90395470
Conjunctivitis 14.56 9.23 94 172679 26612 90429062
Blood immunoglobulin E 14.52 9.23 5 172768 49 90455625
Vascular stent thrombosis 14.51 9.23 14 172759 1102 90454572
Hypercalcaemia 14.44 9.23 27 172746 34213 90421461
Presyncope 14.41 9.23 107 172666 31698 90423976
Infusion site vesicles 14.41 9.23 11 172762 629 90455045
Diplopia 14.41 9.23 99 172674 28615 90427059
Smoke sensitivity 14.35 9.23 10 172763 496 90455178
Punctate keratitis 14.33 9.23 12 172761 784 90454890
Urticaria chronic 14.27 9.23 12 172761 789 90454885
Diabetes mellitus inadequate control 14.24 9.23 9 172764 18675 90436999
Throat clearing 14.24 9.23 26 172747 3821 90451853
Arrhythmia supraventricular 14.23 9.23 14 172759 1128 90454546
Conjunctival oedema 14.21 9.23 13 172760 956 90454718
Reversible cerebral vasoconstriction syndrome 14.15 9.23 27 172746 4103 90451571
Syncope 14.14 9.23 342 172431 132321 90323353
Pneumothorax 14.06 9.23 73 172700 19094 90436580
Myocardial necrosis marker increased 14.05 9.23 19 172754 2159 90453515
Malabsorption from administration site 13.98 9.23 6 172767 111 90455563
Perfume sensitivity 13.92 9.23 13 172760 982 90454692
Middle insomnia 13.85 9.23 66 172707 16685 90438989
Neurogenic shock 13.83 9.23 10 172763 526 90455148
Hyperdynamic left ventricle 13.83 9.23 8 172765 286 90455388
Blood pressure systolic decreased 13.81 9.23 44 172729 9226 90446448
Burning sensation 13.74 9.23 183 172590 63269 90392405
Infusion site inflammation 13.73 9.23 10 172763 532 90455142
Chest crushing 13.72 9.23 3 172770 3 90455671
Oral pruritus 13.63 9.23 22 172751 2929 90452745
Gastric infection 13.61 9.23 26 172747 3954 90451720
Allodynia 13.60 9.23 13 172760 1011 90454663
Procedural anxiety 13.57 9.23 12 172761 844 90454830
Blindness 13.57 9.23 92 172681 26476 90429198
Therapy partial responder 13.53 9.23 80 172693 21963 90433711
Cold urticaria 13.53 9.23 8 172765 298 90455376
Exposure via skin contact 13.46 9.23 48 172725 10657 90445017
Food poisoning 13.46 9.23 30 172743 5088 90450586
Arthritis 13.45 9.23 231 172542 167084 90288590
Sinus operation 13.41 9.23 22 172751 2969 90452705
Administration site scar 13.39 9.23 5 172768 63 90455611
Joint dislocation 13.39 9.23 42 172731 44540 90411134
Infusion site haematoma 13.34 9.23 8 172765 306 90455368
Autonomic neuropathy 13.33 9.23 15 172758 1412 90454262
Mucosal erosion 13.30 9.23 17 172756 1828 90453846
Vaccination complication 13.23 9.23 13 172760 1046 90454628
Normal newborn 13.21 9.23 83 172690 23279 90432395
Migraine 13.19 9.23 465 172308 189927 90265747
Pre-existing condition improved 13.19 9.23 43 172730 9126 90446548
Caffeine allergy 13.18 9.23 4 172769 25 90455649
Hallucination, tactile 13.16 9.23 9 172764 433 90455241
Quadriparesis 13.16 9.23 20 172753 2529 90453145
Anterior chamber fibrin 13.11 9.23 6 172767 130 90455544
Cardiac assistance device user 13.05 9.23 5 172768 68 90455606
Arachnoiditis 13.04 9.23 10 172763 576 90455098
Gastric mucosa erythema 12.94 9.23 9 172764 445 90455229
Product prescribing issue 12.93 9.23 39 172734 7940 90447734
Chondromalacia 12.93 9.23 8 172765 324 90455350
Ejection fraction decreased 12.87 9.23 90 172683 26163 90429511
Tachypnoea 12.87 9.23 77 172696 21232 90434442
Right ventricular dysfunction 12.85 9.23 19 172754 2345 90453329
Infantile apnoea 12.84 9.23 14 172759 1273 90454401
Eye swelling 12.83 9.23 98 172675 29288 90426386
Vascular resistance systemic decreased 12.82 9.23 6 172767 137 90455537
Purpura 12.79 9.23 59 172714 14719 90440955
Blood pressure immeasurable 12.79 9.23 15 172758 1477 90454197
Intraocular pressure increased 12.78 9.23 36 172737 7057 90448617
Skin discomfort 12.76 9.23 17 172756 1904 90453770
Electrocardiogram P wave abnormal 12.75 9.23 7 172766 226 90455448
Vaginal discharge 12.73 9.23 11 172762 19453 90436221
Blood bicarbonate decreased 12.73 9.23 22 172751 3097 90452577
Eye infarction 12.73 9.23 5 172768 73 90455601
Eye movement disorder 12.71 9.23 33 172740 6165 90449509
Transaminases increased 12.67 9.23 33 172740 37159 90418515
Colour blindness 12.67 9.23 8 172765 336 90455338
Subcutaneous drug absorption impaired 12.61 9.23 5 172768 13540 90442134
Hypoproteinaemia 12.61 9.23 22 172751 3120 90452554
Central venous catheter removal 12.61 9.23 9 172764 464 90455210
Uterine atony 12.58 9.23 8 172765 340 90455334
Neonatal seizure 12.58 9.23 10 172763 607 90455067
Pruritus 12.56 9.23 1197 171576 540328 89915346
Spinal synovial cyst 12.54 9.23 5 172768 76 90455598
Allergic cough 12.54 9.23 13 172760 1115 90454559
Conduction disorder 12.53 9.23 16 172757 1719 90453955
Glycogen storage disease type II 12.51 9.23 3 172770 6 90455668
Vaccination site rash 12.51 9.23 3 172770 6 90455668
Brain stent insertion 12.51 9.23 3 172770 6 90455668
Nerve root injury cervical 12.51 9.23 3 172770 6 90455668
Tonic posturing 12.51 9.23 3 172770 6 90455668
Capillary nail refill test abnormal 12.48 9.23 5 172768 77 90455597
Chronic obstructive pulmonary disease 12.48 9.23 204 172569 73625 90382049
Conjunctivitis allergic 12.44 9.23 14 172759 1318 90454356
Heliotrope rash 12.42 9.23 7 172766 238 90455436
Propofol infusion syndrome 12.38 9.23 14 172759 1325 90454349
Disease recurrence 12.38 9.23 34 172739 37619 90418055
Injection site oedema 12.33 9.23 16 172757 1747 90453927
Left ventricular dysfunction 12.28 9.23 58 172715 14611 90441063
Vocal cord disorder 12.25 9.23 15 172758 1545 90454129
Quadriplegia 12.22 9.23 18 172755 2213 90453461
Scratch 12.21 9.23 44 172729 9822 90445852
Electrocardiogram QT prolonged 12.17 9.23 200 172573 72256 90383418
Hordeolum 12.16 9.23 28 172745 4850 90450824
Dysphagia 12.13 9.23 290 172483 111988 90343686
Exophthalmos 12.05 9.23 16 172757 1786 90453888
Adverse reaction 12.04 9.23 24 172749 29688 90425986
Psychotic disorder 12.00 9.23 26 172747 31204 90424470
Nail bed tenderness 11.98 9.23 8 172765 370 90455304
Nodal rhythm 11.94 9.23 16 172757 1802 90453872
Gastrointestinal infection 11.93 9.23 47 172726 10943 90444731
Accelerated idioventricular rhythm 11.93 9.23 5 172768 87 90455587
Chemical burn 11.92 9.23 9 172764 506 90455168
Paraesthesia oral 11.88 9.23 102 172671 31557 90424117
Parosmia 11.88 9.23 35 172738 7034 90448640
Drug tolerance 11.87 9.23 10 172763 17906 90437768
Thermal burn 11.87 9.23 34 172739 6728 90448946
Apgar score low 11.85 9.23 13 172760 1190 90454484
Device related infection 11.83 9.23 87 172686 25699 90429975
Respiratory arrest 11.82 9.23 106 172667 33205 90422469
Injection site bruising 11.80 9.23 152 172621 52155 90403519
Pneumonia mycoplasmal 11.76 9.23 12 172761 1010 90454664
Norovirus infection 11.76 9.23 16 172757 1828 90453846
Incision site rash 11.73 9.23 4 172769 38 90455636
Food allergy 11.71 9.23 86 172687 25392 90430282
Base excess decreased 11.67 9.23 5 172768 92 90455582
Cardiac failure congestive 11.64 9.23 126 172647 98568 90357106
Heparin-induced thrombocytopenia 11.64 9.23 29 172744 5283 90450391
Blood immunoglobulin G abnormal 11.63 9.23 4 172769 39 90455635
Infected bite 11.61 9.23 17 172756 2080 90453594
Vascular stenosis 11.60 9.23 9 172764 527 90455147
Transferrin decreased 11.60 9.23 8 172765 390 90455284
Eosinophilia 11.60 9.23 23 172750 28510 90427164
Respiratory syncytial virus infection 11.52 9.23 45 172728 10435 90445239
Cutis laxa 11.51 9.23 6 172767 174 90455500
Gastroenteritis 11.51 9.23 24 172749 29205 90426469
Atrioventricular block complete 11.50 9.23 43 172730 9768 90445906
Electrocardiogram U wave present 11.48 9.23 5 172768 96 90455578
Device wireless communication issue 11.48 9.23 5 172768 96 90455578
Incision site swelling 11.46 9.23 7 172766 277 90455397
Injection site abscess 11.45 9.23 14 172759 1440 90454234
XIIth nerve injury 11.41 9.23 3 172770 10 90455664
Spinal operation 11.39 9.23 44 172729 10152 90445522
Electrocardiogram QRS complex shortened 11.37 9.23 9 172764 543 90455131
Vitreous haemorrhage 11.35 9.23 19 172754 2607 90453067
Tidal volume decreased 11.28 9.23 4 172769 43 90455631
Deafness permanent 11.24 9.23 9 172764 552 90455122
Epinephrine increased 11.19 9.23 3 172770 11 90455663
Device use issue 11.18 9.23 23 172750 3690 90451984
Eyelid contusion 11.16 9.23 5 172768 103 90455571
Muscle tension dysphonia 11.13 9.23 7 172766 292 90455382
Implant site bruising 11.11 9.23 8 172765 418 90455256
Poor quality product administered 11.11 9.23 24 172749 3984 90451690
Sialoadenitis 11.09 9.23 17 172756 2165 90453509
Injection site necrosis 11.09 9.23 14 172759 1487 90454187
Incorrect product formulation administered 11.09 9.23 6 172767 188 90455486
Cataract nuclear 11.08 9.23 12 172761 1082 90454592
Gingival pain 11.06 9.23 42 172731 9610 90446064
Somnolence 11.06 9.23 496 172277 208588 90247086
Brain death 11.06 9.23 24 172749 3997 90451677
Spinal cord oedema 11.03 9.23 6 172767 190 90455484
Hyperventilation 11.01 9.23 33 172740 6695 90448979
Medical device site infection 11.00 9.23 8 172765 425 90455249
Low cardiac output syndrome 11.00 9.23 8 172765 425 90455249
Pulse pressure decreased 10.97 9.23 6 172767 192 90455482
Panniculitis 10.97 9.23 7 172766 14451 90441223
Anaesthetic complication cardiac 10.97 9.23 4 172769 47 90455627
Spinal cord injury 10.95 9.23 12 172761 1097 90454577
Airway complication of anaesthesia 10.95 9.23 8 172765 428 90455246
Bradyarrhythmia 10.90 9.23 18 172755 2443 90453231
Blood calcium decreased 10.89 9.23 26 172747 30156 90425518
Atrial flutter 10.87 9.23 45 172728 10713 90444961
Ocular retrobulbar haemorrhage 10.86 9.23 5 172768 110 90455564
Allergy to immunoglobulin therapy 10.83 9.23 6 172767 197 90455477
Myocardial stunning 10.83 9.23 7 172766 306 90455368
Product administered to patient of inappropriate age 10.83 9.23 26 172747 4627 90451047
Sudden visual loss 10.82 9.23 4 172769 49 90455625
Supraventricular extrasystoles 10.79 9.23 28 172745 5229 90450445
Peritonitis 10.77 9.23 13 172760 19692 90435982
Orbital infection 10.77 9.23 5 172768 112 90455562
Vision blurred 10.77 9.23 281 172492 110012 90345662
Troponin increased 10.75 9.23 52 172721 13229 90442445
Cardiac arrest neonatal 10.73 9.23 5 172768 113 90455561
Poikiloderma 10.73 9.23 7 172766 311 90455363
Myasthenia gravis 10.73 9.23 33 172740 6792 90448882
Vein discolouration 10.71 9.23 7 172766 312 90455362
Foreign body in respiratory tract 10.69 9.23 7 172766 313 90455361
Cerebral congestion 10.69 9.23 5 172768 114 90455560
Joint destruction 10.69 9.23 6 172767 13281 90442393
N-terminal prohormone brain natriuretic peptide 10.67 9.23 4 172769 51 90455623
Mechanical urticaria 10.66 9.23 9 172764 595 90455079
Ventricular tachyarrhythmia 10.62 9.23 6 172767 205 90455469
Lacrimation increased 10.59 9.23 88 172685 26974 90428700
Pancreatitis acute 10.56 9.23 29 172744 32086 90423588
Product administered at inappropriate site 10.54 9.23 24 172749 4127 90451547
Mania 10.50 9.23 7 172766 14117 90441557
Iron binding capacity total decreased 10.47 9.23 8 172765 458 90455216
Allergic reaction to excipient 10.46 9.23 10 172763 778 90454896
Administration site urticaria 10.45 9.23 3 172770 15 90455659
Vitamin E decreased 10.45 9.23 3 172770 15 90455659
Attention deficit hyperactivity disorder 10.42 9.23 24 172749 4160 90451514
Candida infection 10.41 9.23 105 172668 33952 90421722
Acidosis 10.40 9.23 50 172723 12686 90442988
Blood bilirubin increased 10.40 9.23 45 172728 43425 90412249
Eye injury 10.38 9.23 4 172769 11016 90444658
Vulvovaginal swelling 10.37 9.23 10 172763 786 90454888
Cytomegalovirus infection 10.34 9.23 22 172751 26580 90429094
Labelled drug-drug interaction medication error 10.33 9.23 55 172718 14527 90441147
Facial discomfort 10.31 9.23 7 172766 333 90455341
Schizophrenia 10.29 9.23 8 172765 14906 90440768
Anal sphincter atony 10.25 9.23 7 172766 336 90455338
Lip disorder 10.24 9.23 14 172759 1608 90454066
Catheter site haemorrhage 10.21 9.23 22 172751 3646 90452028
Floppy infant 10.20 9.23 5 172768 127 90455547
Product leakage 10.19 9.23 13 172760 1395 90454279
Reaction to excipient 10.18 9.23 15 172758 1845 90453829
Muscle strain 10.17 9.23 41 172732 9646 90446028
Herpes dermatitis 10.16 9.23 5 172768 128 90455546
Maternal exposure timing unspecified 10.14 9.23 17 172756 22466 90433208
Circumstance or information capable of leading to device use error 10.14 9.23 6 172767 224 90455450
Skin warm 10.13 9.23 35 172738 7652 90448022
Body temperature abnormal 10.10 9.23 18 172755 2597 90453077
Respiratory rate decreased 10.08 9.23 23 172750 3960 90451714
Pneumocystis jirovecii pneumonia 10.07 9.23 16 172757 21600 90434074
Oxygen saturation abnormal 10.02 9.23 24 172749 4264 90451410
Splenic infarction 10.02 9.23 16 172757 2111 90453563
Haemorrhoids 10.01 9.23 86 172687 26616 90429058
Eclampsia 10.00 9.23 8 172765 490 90455184
Metastases to bone 9.99 9.23 21 172752 25484 90430190
Vein rupture 9.98 9.23 14 172759 1647 90454027
Wrong technique in device usage process 9.91 9.23 29 172744 5806 90449868
Death 9.86 9.23 743 172030 455808 89999866
Idiopathic urticaria 9.86 9.23 7 172766 358 90455316
Victim of spousal abuse 9.85 9.23 3 172770 19 90455655
Allergy to metals 9.83 9.23 11 172762 1029 90454645
Forced vital capacity abnormal 9.79 9.23 4 172769 65 90455609
Urticarial vasculitis 9.79 9.23 11 172762 1034 90454640
Parasomnia 9.78 9.23 9 172764 667 90455007
Dry eye 9.76 9.23 160 172613 57771 90397903
Cardiomyopathy 9.74 9.23 69 172704 20137 90435537
Drug dose omission by device 9.72 9.23 42 172731 10189 90445485
Sinusitis bacterial 9.68 9.23 15 172758 1928 90453746
Procedural failure 9.68 9.23 4 172769 67 90455607
Arthritis fungal 9.68 9.23 4 172769 67 90455607
Reflux laryngitis 9.65 9.23 6 172767 245 90455429
Myasthenia gravis crisis 9.63 9.23 11 172762 1053 90454621
Meningitis bacterial 9.62 9.23 14 172759 1703 90453971
Rash macular 9.56 9.23 94 172679 30186 90425488
Female genital tract fistula 9.55 9.23 12 172761 17856 90437818
Hypertensive emergency 9.53 9.23 16 172757 2201 90453473
Constipation 9.52 9.23 437 172336 279958 90175716
Anaphylactoid syndrome of pregnancy 9.52 9.23 4 172769 70 90455604
Cardiac index decreased 9.52 9.23 4 172769 70 90455604
Drug eruption 9.52 9.23 35 172738 35372 90420302
Economic problem 9.50 9.23 20 172753 3261 90452413
Lung neoplasm malignant 9.50 9.23 20 172753 24253 90431421
Vasculitis 9.48 9.23 18 172755 22675 90432999
Hyperhidrosis 9.46 9.23 333 172440 135972 90319702
Arthropod sting 9.43 9.23 12 172761 1285 90454389
Scintillating scotoma 9.41 9.23 5 172768 151 90455523
Vaginal abscess 9.41 9.23 8 172765 534 90455140
Intercepted medication error 9.37 9.23 10 172763 887 90454787
Anaesthetic complication pulmonary 9.37 9.23 4 172769 73 90455601
Intraocular pressure fluctuation 9.37 9.23 4 172769 73 90455601
Aplastic anaemia 9.37 9.23 50 172723 13219 90442455
Iris hypopigmentation 9.36 9.23 3 172770 23 90455651
Propionibacterium infection 9.36 9.23 3 172770 23 90455651
Scarlet fever 9.35 9.23 5 172768 153 90455521
Tachyarrhythmia 9.31 9.23 27 172746 5379 90450295
Respiratory tract oedema 9.28 9.23 9 172764 713 90454961
Ocular discomfort 9.28 9.23 30 172743 6340 90449334
Ischaemic hepatitis 9.25 9.23 18 172755 2775 90452899

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 655 10.87 3009 94772 627188 41896366
Local anaesthetic systemic toxicity 647.52 10.87 231 97550 2069 42521485
Anaphylactic shock 441.93 10.87 393 97388 23124 42500430
Anaphylactic reaction 438.12 10.87 515 97266 42228 42481326
Device failure 413.38 10.87 175 97606 2568 42520986
Cardiac arrest 324.75 10.87 751 97030 108569 42414985
Sinusitis 250.73 10.87 415 97366 46877 42476677
Anaesthetic complication 223.02 10.87 94 97687 1363 42522191
Hereditary angioedema 188.88 10.87 84 97697 1397 42522157
Toxic anterior segment syndrome 179.58 10.87 80 97701 1336 42522218
Methaemoglobinaemia 164.41 10.87 123 97658 5651 42517903
Kounis syndrome 156.18 10.87 97 97684 3271 42520283
Inspiratory capacity decreased 151.80 10.87 91 97690 2876 42520678
Chondrolysis 148.90 10.87 38 97743 84 42523470
Bradycardia 139.05 10.87 472 97309 85012 42438542
Stress cardiomyopathy 136.25 10.87 83 97698 2702 42520852
Injury 134.91 10.87 208 97573 22108 42501446
Impaired quality of life 130.72 10.87 162 97619 14015 42509539
Fear 128.99 10.87 142 97639 10823 42512731
Hypotension 127.47 10.87 1018 96763 256613 42266941
Infusion site pain 125.55 10.87 102 97679 5293 42518261
Ear infection 122.40 10.87 149 97632 12655 42510899
Product quality issue 119.97 10.87 175 97606 17707 42505847
Dermatitis atopic 119.64 10.87 145 97636 12259 42511295
Ventricular fibrillation 117.00 10.87 231 97550 29892 42493662
Ventricular tachycardia 115.60 10.87 230 97551 29930 42493624
Renal injury 114.31 10.87 141 97640 12139 42511415
Accidental overdose 113.37 10.87 220 97561 28110 42495444
Drug ineffective for unapproved indication 113.29 10.87 295 97486 45868 42477686
Stress 112.08 10.87 286 97495 43926 42479628
Infusion site swelling 111.70 10.87 78 97703 3214 42520340
Emotional distress 107.25 10.87 157 97624 15936 42507618
Diarrhoea 105.74 10.87 623 97158 460226 42063328
Electrocardiogram ST segment elevation 103.15 10.87 95 97686 5844 42517710
Arteriospasm coronary 100.71 10.87 85 97696 4653 42518901
Infusion site extravasation 99.74 10.87 90 97691 5391 42518163
Needle issue 97.47 10.87 110 97671 8617 42514937
Anhedonia 96.97 10.87 103 97678 7537 42516017
Injection site pallor 96.36 10.87 20 97761 6 42523548
Interstitial lung disease 94.59 10.87 31 97750 78431 42445123
Incorrect route of product administration 91.52 10.87 184 97597 24121 42499433
Swollen tongue 90.03 10.87 169 97612 21062 42502492
Injection site laceration 89.33 10.87 20 97761 17 42523537
Cardiogenic shock 88.72 10.87 229 97552 35411 42488143
Injury associated with device 87.84 10.87 49 97732 1348 42522206
Infusion site erythema 87.51 10.87 70 97711 3552 42520002
Vasoplegia syndrome 85.65 10.87 61 97720 2594 42520960
Bronchospasm 84.84 10.87 125 97656 12760 42510794
Accidental exposure to product 82.36 10.87 159 97622 20234 42503320
Disease progression 81.68 10.87 127 97654 143529 42380025
Acute kidney injury 79.72 10.87 505 97276 366832 42156722
Lagophthalmos 79.69 10.87 24 97757 117 42523437
Neutropenia 77.47 10.87 219 97562 199212 42324342
Anaemia 76.36 10.87 357 97424 279921 42243633
Thrombocytopenia 75.35 10.87 207 97574 190072 42333482
Generalised tonic-clonic seizure 74.62 10.87 178 97603 26201 42497353
Insurance issue 73.74 10.87 67 97714 4049 42519505
Shock 72.36 10.87 187 97594 28934 42494620
Accidental exposure to product by child 72.32 10.87 45 97736 1522 42522032
General physical health deterioration 72.23 10.87 149 97632 151097 42372457
Pain 71.07 10.87 866 96915 243982 42279572
Overdose 70.55 10.87 448 97333 104816 42418738
Tachycardia 70.10 10.87 434 97347 100653 42422901
Liquid product physical issue 69.65 10.87 35 97746 774 42522780
Burns second degree 68.35 10.87 77 97704 6019 42517535
Catarrh 67.78 10.87 76 97705 5910 42517644
Electrocardiogram QRS complex prolonged 67.78 10.87 75 97706 5748 42517806
Illness 67.07 10.87 165 97616 24765 42498789
Asthenia 66.66 10.87 375 97406 280418 42243136
Decreased appetite 66.54 10.87 224 97557 192913 42330641
Hypopnoea 66.21 10.87 86 97695 7796 42515758
Hypoxic-ischaemic encephalopathy 65.79 10.87 70 97711 5132 42518422
Cauda equina syndrome 63.34 10.87 35 97746 945 42522609
Rhinitis 63.27 10.87 105 97676 11872 42511682
Device use issue 63.24 10.87 35 97746 948 42522606
Infusion site pruritus 62.67 10.87 37 97744 1136 42522418
Pancytopenia 62.34 10.87 109 97672 117634 42405920
Death 62.30 10.87 737 97044 470448 42053106
Expired product administered 61.67 10.87 61 97720 4102 42519452
Unevaluable event 60.76 10.87 195 97586 34093 42489461
Urticaria 59.16 10.87 330 97451 73706 42449848
Unresponsive to stimuli 58.77 10.87 182 97599 31221 42492333
Malignant neoplasm progression 58.62 10.87 99 97682 108301 42415253
Parosmia 58.59 10.87 80 97701 7611 42515943
Haemodynamic instability 58.35 10.87 104 97677 12453 42511101
Completed suicide 58.00 10.87 82 97699 96383 42427171
Toxicity to various agents 57.84 10.87 790 96991 228346 42295208
Leukopenia 57.51 10.87 52 97729 74694 42448860
Steroid dependence 57.49 10.87 74 97707 6648 42516906
Medication error 54.67 10.87 184 97597 32970 42490584
Systemic lupus erythematosus 53.69 10.87 85 97696 9239 42514315
Coagulation factor deficiency 53.09 10.87 21 97760 256 42523298
Factor V Leiden mutation 52.57 10.87 20 97761 218 42523336
Gingival pain 52.49 10.87 80 97701 8414 42515140
Multiple allergies 52.24 10.87 53 97728 3675 42519879
Upper respiratory tract infection 51.91 10.87 213 97568 41960 42481594
Hyperthermia malignant 51.05 10.87 45 97736 2613 42520941
Injection site injury 50.01 10.87 22 97759 356 42523198
Hypersensitivity 49.70 10.87 310 97471 72060 42451494
Sinus tachycardia 49.64 10.87 131 97650 20522 42503032
Injection site pain 49.11 10.87 262 97519 57536 42466018
Wrong product administered 47.79 10.87 65 97716 6161 42517393
Pulse absent 46.98 10.87 65 97716 6262 42517292
Haemoglobin decreased 46.72 10.87 152 97629 132319 42391235
Medical device entrapment 45.72 10.87 9 97772 0 42523554
COVID-19 45.10 10.87 435 97346 115513 42408041
Coagulation factor V level abnormal 44.86 10.87 16 97765 143 42523411
Cardiac failure congestive 44.61 10.87 80 97701 85522 42438032
Systolic anterior motion of mitral valve 44.40 10.87 12 97769 36 42523518
White blood cell count decreased 43.72 10.87 120 97661 110276 42413278
Endophthalmitis 43.03 10.87 52 97729 4381 42519173
Rheumatoid arthritis 42.67 10.87 22 97759 42418 42481136
Anal inflammation 41.34 10.87 37 97744 2192 42521362
Migraine 40.97 10.87 140 97641 25274 42498280
Spinal cord infarction 40.90 10.87 23 97758 643 42522911
Trigemino-cardiac reflex 40.86 10.87 19 97762 352 42523202
Asthma 40.36 10.87 263 97518 62051 42461503
Cardiotoxicity 40.31 10.87 66 97715 7379 42516175
Dehydration 40.06 10.87 178 97603 141589 42381965
Psoriasis 39.59 10.87 32 97749 48572 42474982
Pulseless electrical activity 39.35 10.87 70 97711 8367 42515187
Agranulocytosis 38.86 10.87 11 97770 30601 42492953
Multiple organ dysfunction syndrome 38.19 10.87 365 97416 96670 42426884
Respiratory tract infection 38.14 10.87 140 97641 26182 42497372
SARS-CoV-2 test negative 38.05 10.87 32 97749 1743 42521811
Metabolic acidosis 38.04 10.87 226 97555 51632 42471922
Adulterated product 37.91 10.87 23 97758 743 42522811
Eczema 37.19 10.87 166 97615 33920 42489634
Inappropriate schedule of product administration 36.89 10.87 359 97422 95543 42428011
Injection site coldness 36.76 10.87 10 97771 31 42523523
Apnoea 36.73 10.87 65 97716 7738 42515816
Hypoxia 36.13 10.87 279 97502 69507 42454047
Corneal reflex decreased 35.52 10.87 14 97767 169 42523385
Corneal oedema 35.45 10.87 29 97752 1519 42522035
No adverse event 35.29 10.87 180 97601 38841 42484713
Nasopharyngitis 35.08 10.87 320 97461 83676 42439878
Platelet count decreased 35.06 10.87 181 97600 138400 42385154
Respiratory depression 34.97 10.87 109 97672 18759 42504795
Seizure like phenomena 34.92 10.87 25 97756 1072 42522482
Post procedural complication 34.57 10.87 84 97697 12506 42511048
Alcohol poisoning 34.25 10.87 62 97719 7512 42516042
Retinal artery occlusion 33.83 10.87 33 97748 2182 42521372
Cardiac murmur 33.77 10.87 84 97697 12691 42510863
Myelosuppression 33.76 10.87 26 97755 40435 42483119
Melaena 33.49 10.87 24 97757 38722 42484832
Oedema peripheral 33.16 10.87 180 97601 135896 42387658
Coronary artery disease 32.94 10.87 45 97736 53675 42469879
Product use in unapproved indication 32.47 10.87 599 97182 183857 42339697
Prostate cancer 32.07 10.87 33 97748 44610 42478944
Brain oedema 31.83 10.87 96 97685 16231 42507323
Angioedema 31.72 10.87 186 97595 42291 42481263
Neuromuscular block prolonged 31.70 10.87 19 97762 600 42522954
Accident 31.69 10.87 55 97726 6448 42517106
Drug-induced liver injury 31.42 10.87 25 97756 38248 42485306
Mydriasis 31.35 10.87 65 97716 8705 42514849
Medical device site laceration 30.48 10.87 6 97775 0 42523554
Infusion site rash 30.42 10.87 19 97762 647 42522907
Pancreatitis acute 30.06 10.87 20 97761 33544 42490010
International normalised ratio increased 29.88 10.87 40 97741 48128 42475426
Loss of consciousness 29.51 10.87 333 97448 92021 42431533
Infusion site haemorrhage 29.41 10.87 24 97757 1253 42522301
Gastrointestinal haemorrhage 29.25 10.87 120 97661 97606 42425948
Status epilepticus 28.88 10.87 90 97691 15488 42508066
Respiratory acidosis 28.85 10.87 52 97729 6279 42517275
Myalgia 28.74 10.87 118 97663 95962 42427592
Left ventricle outflow tract obstruction 28.72 10.87 12 97769 170 42523384
Infusion site bruising 28.72 10.87 21 97760 931 42522623
Myocardial infarction 28.60 10.87 167 97614 123842 42399712
Foetal exposure during delivery 28.50 10.87 11 97770 125 42523429
Removal of foreign body 28.24 10.87 7 97774 13 42523541
Administration site pain 28.11 10.87 16 97765 458 42523096
Pulmonary fibrosis 28.08 10.87 13 97768 26668 42496886
Seasonal allergy 27.98 10.87 59 97722 7996 42515558
Cytomegalovirus infection 27.93 10.87 20 97761 32286 42491268
Dyspnoea exertional 27.83 10.87 45 97736 50103 42473451
Therapy non-responder 27.43 10.87 213 97568 53146 42470408
Circulatory collapse 27.22 10.87 117 97664 23519 42500035
Incorrect drug administration rate 27.20 10.87 29 97752 2131 42521423
Paraesthesia oral 26.92 10.87 45 97736 5118 42518436
Hyperdynamic left ventricle 26.57 10.87 13 97768 271 42523283
Impaired work ability 26.36 10.87 74 97707 12017 42511537
Ventricular extrasystoles 26.35 10.87 79 97702 13311 42510243
Neoplasm progression 26.35 10.87 17 97764 28983 42494571
Orthostatic hypotension 26.33 10.87 19 97762 30551 42493003
Blood pressure decreased 26.29 10.87 226 97555 58106 42465448
Infusion site nodule 26.28 10.87 10 97771 109 42523445
Drug resistance 26.12 10.87 24 97757 34224 42489330
Hypoglycaemia 26.05 10.87 62 97719 59792 42463762
Pharyngitis streptococcal 25.91 10.87 38 97743 3862 42519692
Procedural haemorrhage 25.44 10.87 32 97749 2809 42520745
Ventricular arrhythmia 25.40 10.87 49 97732 6230 42517324
Administration site swelling 25.11 10.87 12 97769 237 42523317
Delayed recovery from anaesthesia 24.90 10.87 21 97760 1148 42522406
Hepatitis 24.81 10.87 16 97765 27284 42496270
Electrocardiogram ST segment depression 24.78 10.87 31 97750 2706 42520848
Tryptase increased 24.72 10.87 13 97768 317 42523237
Dry gangrene 24.52 10.87 15 97766 492 42523062
Coma 24.41 10.87 208 97573 53346 42470208
Respiratory arrest 24.24 10.87 129 97652 28295 42495259
Cardiac failure 24.06 10.87 145 97636 106711 42416843
Discomfort 23.98 10.87 118 97663 25101 42498453
Cholestasis 23.96 10.87 24 97757 32855 42490699
Oxygen saturation decreased 23.82 10.87 240 97541 64447 42459107
Laryngeal oedema 23.71 10.87 37 97744 3971 42519583
Procedural complication 23.65 10.87 38 97743 4181 42519373
Drug interaction 23.60 10.87 451 97330 266548 42257006
Myocardial stunning 23.59 10.87 6 97775 13 42523541
Erythema 23.39 10.87 365 97416 108428 42415126
Suicide attempt 23.19 10.87 44 97737 46056 42477498
Polyneuropathy 23.14 10.87 7 97774 18654 42504900
Tinnitus 23.10 10.87 129 97652 28809 42494745
Chronic kidney disease 22.98 10.87 46 97735 47195 42476359
Bronchiectasis 22.95 10.87 92 97689 17927 42505627
Mean arterial pressure decreased 22.80 10.87 11 97770 222 42523332
Hepatocellular injury 22.74 10.87 13 97768 23665 42499889
Pneumocystis jirovecii pneumonia 22.55 10.87 15 97766 25166 42498388
Seizure 22.42 10.87 395 97386 120166 42403388
Disease recurrence 22.40 10.87 21 97760 29657 42493897
Oculocardiac reflex 22.30 10.87 9 97772 116 42523438
Jaundice 22.20 10.87 28 97753 34561 42488993
Distributive shock 22.17 10.87 28 97753 2468 42521086
Eyelid rash 22.17 10.87 9 97772 118 42523436
Sinus arrest 22.10 10.87 26 97755 2130 42521424
Transient ischaemic attack 21.98 10.87 27 97754 33712 42489842
Bladder cancer 21.87 10.87 6 97775 17041 42506513
Quadriplegia 21.80 10.87 26 97755 2161 42521393
Anaesthetic complication neurological 21.67 10.87 16 97765 720 42522834
Negative pressure pulmonary oedema 21.65 10.87 15 97766 610 42522944
Diabetes insipidus 21.58 10.87 34 97747 3679 42519875
Croup infectious 21.31 10.87 14 97767 521 42523033
Proctalgia 21.29 10.87 49 97732 7044 42516510
Hepatic function abnormal 21.20 10.87 55 97726 51512 42472042
Torsade de pointes 21.15 10.87 55 97726 8539 42515015
Cyanosis 20.98 10.87 79 97702 14952 42508602
Injection site hypoaesthesia 20.95 10.87 9 97772 137 42523417
Pharyngeal swelling 20.92 10.87 32 97749 3375 42520179
Headache 20.91 10.87 707 97074 238662 42284892
Infusion site reaction 20.84 10.87 20 97761 1296 42522258
Device malfunction 20.83 10.87 69 97712 12258 42511296
Haematuria 20.58 10.87 66 97715 57733 42465821
Poor venous access 20.57 10.87 49 97732 7203 42516351
Brain stem syndrome 20.57 10.87 15 97766 662 42522892
Drug reaction with eosinophilia and systemic symptoms 20.44 10.87 41 97740 42034 42481520
Full blood count abnormal 20.44 10.87 23 97758 29853 42493701
Blood creatinine increased 20.42 10.87 158 97623 109845 42413709
Vasoconstriction 20.38 10.87 11 97770 283 42523271
Hepatic cytolysis 20.25 10.87 19 97762 26825 42496729
Mean arterial pressure increased 20.20 10.87 7 97774 57 42523497
Infusion site discharge 20.02 10.87 12 97769 379 42523175
Bone marrow failure 20.00 10.87 28 97753 33065 42490489
Infusion site irritation 19.88 10.87 12 97769 384 42523170
Angina pectoris 19.72 10.87 28 97753 32868 42490686
Malaise 19.47 10.87 356 97425 211800 42311754
Macroglossia 19.43 10.87 13 97768 499 42523055
Injection site discolouration 19.36 10.87 23 97758 1903 42521651
Procedural hypotension 19.30 10.87 17 97764 986 42522568
Lymphopenia 19.10 10.87 13 97768 21550 42502004
Administration related reaction 19.10 10.87 9 97772 172 42523382
Administration site erythema 19.02 10.87 7 97774 69 42523485
Liver disorder 18.94 10.87 39 97742 39605 42483949
Hypopyon 18.91 10.87 13 97768 522 42523032
Tracheitis 18.78 10.87 17 97764 1022 42522532
Gastroenteritis viral 18.69 10.87 51 97730 8148 42515406
Macular ischaemia 18.68 10.87 9 97772 181 42523373
Neuromuscular blockade 18.57 10.87 11 97770 340 42523214
Corneal opacity 18.56 10.87 14 97767 651 42522903
Chemical burn 18.51 10.87 11 97770 342 42523212
Embolia cutis medicamentosa 18.48 10.87 11 97770 343 42523211
Viral infection 18.46 10.87 101 97680 22382 42501172
Open globe injury 18.42 10.87 7 97774 76 42523478
Injection site scar 18.40 10.87 12 97769 441 42523113
Paralysis 18.39 10.87 46 97735 6974 42516580
Pupillary reflex impaired 18.37 10.87 21 97760 1668 42521886
Intentional self-injury 18.32 10.87 6 97775 15196 42508358
Food allergy 18.29 10.87 24 97757 2197 42521357
Aqueous fibrin 18.26 10.87 7 97774 78 42523476
Hyponatraemia 18.25 10.87 147 97634 101315 42422239
Haemolytic anaemia 18.14 10.87 3 97778 12124 42511430
Colitis 18.14 10.87 51 97730 46521 42477033
Anxiety 18.13 10.87 377 97404 118183 42405371
Blood pressure fluctuation 18.10 10.87 21 97760 26887 42496667
Treatment noncompliance 18.05 10.87 37 97744 37635 42485919
Syncope 17.88 10.87 144 97637 99262 42424292
Musculoskeletal stiffness 17.87 10.87 70 97711 57695 42465859
Anaphylactoid shock 17.83 10.87 12 97769 465 42523089
Pupil fixed 17.82 10.87 22 97759 1895 42521659
Post cardiac arrest syndrome 17.81 10.87 5 97776 18 42523536
Product dose omission issue 17.81 10.87 472 97309 153893 42369661
Hepatotoxicity 17.63 10.87 19 97762 25148 42498406
Bronchopulmonary aspergillosis allergic 17.53 10.87 35 97746 4563 42518991
Insomnia 17.49 10.87 180 97601 118073 42405481
C-reactive protein increased 17.22 10.87 81 97700 63479 42460075
Neuropathy peripheral 17.21 10.87 150 97631 101703 42421851
Laryngospasm 17.18 10.87 22 97759 1966 42521588
Product distribution issue 17.13 10.87 22 97759 1972 42521582
Chondromalacia 17.02 10.87 5 97776 22 42523532
Alanine aminotransferase increased 16.87 10.87 126 97655 88280 42435274
Product administration interrupted 16.82 10.87 36 97745 4930 42518624
Toxic epidermal necrolysis 16.81 10.87 22 97759 26728 42496826
Blood phosphorus increased 16.80 10.87 65 97716 12460 42511094
Diabetic ketoacidosis 16.67 10.87 16 97765 22351 42501203
Coma neonatal 16.66 10.87 5 97776 24 42523530
Blood creatine phosphokinase increased 16.65 10.87 56 97725 48282 42475272
Anal sphincter atony 16.65 10.87 8 97773 160 42523394
Constipation 16.60 10.87 267 97514 162024 42361530
Spinal meningeal cyst 16.57 10.87 7 97774 102 42523452
Nephropathy toxic 16.52 10.87 9 97772 16829 42506725
Familial periodic paralysis 16.51 10.87 8 97773 163 42523391
Respiratory tract infection bacterial 16.30 10.87 21 97760 1888 42521666
Full blood count decreased 16.17 10.87 14 97767 20546 42503008
Drug intolerance 16.13 10.87 113 97668 80311 42443243
Phrenic nerve injury 15.94 10.87 4 97777 8 42523546
Hypercalcaemia 15.85 10.87 11 97770 18047 42505507
Gait disturbance 15.83 10.87 146 97635 97854 42425700
Abdominal pain 15.82 10.87 325 97456 190146 42333408
Type I hypersensitivity 15.70 10.87 22 97759 2144 42521410
Pulmonary oedema 15.64 10.87 189 97592 53083 42470471
Metastases to liver 15.63 10.87 9 97772 16317 42507237
Eosinophilic oesophagitis 15.60 10.87 13 97768 699 42522855
Frequent bowel movements 15.50 10.87 93 97688 21314 42502240
Ophthalmoplegia 15.44 10.87 22 97759 2178 42521376
Postoperative delirium 15.36 10.87 12 97769 588 42522966
Liver function test abnormal 15.36 10.87 32 97749 32359 42491195
Administration site irritation 15.33 10.87 4 97777 10 42523544
Administration site scar 15.24 10.87 3 97778 0 42523554
General anaesthesia 15.24 10.87 3 97778 0 42523554
Eye infection 15.21 10.87 32 97749 4329 42519225
Plasma cell myeloma 15.13 10.87 57 97724 47521 42476033
Cardiac arrest neonatal 14.96 10.87 5 97776 36 42523518
Hypothyroidism 14.96 10.87 32 97749 32052 42491502
Infusion site mass 14.94 10.87 10 97771 384 42523170
Multiple sclerosis relapse 14.93 10.87 7 97774 14257 42509297
Paraplegia 14.92 10.87 27 97754 3270 42520284
Meningococcal sepsis 14.89 10.87 6 97775 77 42523477
Dyspepsia 14.87 10.87 47 97734 41305 42482249
Fatigue 14.84 10.87 833 96948 434808 42088746
Fall 14.84 10.87 417 97364 234103 42289451
Ventricular asystole 14.83 10.87 9 97772 291 42523263
Brugada syndrome 14.81 10.87 15 97766 1038 42522516
Electrocardiogram ST segment abnormal 14.80 10.87 13 97768 751 42522803
Pleural effusion 14.74 10.87 147 97634 97019 42426535
Gamma-glutamyltransferase increased 14.67 10.87 33 97748 32464 42491090
Neuralgia 14.66 10.87 105 97676 25542 42498012
Hallucination 14.59 10.87 75 97706 57432 42466122
Drug-disease interaction 14.52 10.87 14 97767 912 42522642
Colitis ulcerative 14.30 10.87 106 97675 26069 42497485
Neutrophil count decreased 14.29 10.87 86 97695 63329 42460225
Peritonitis 14.28 10.87 13 97768 18620 42504934
Arthropathy 14.24 10.87 29 97752 29568 42493986
Anoxia 14.23 10.87 6 97775 87 42523467
Neuroleptic malignant syndrome 14.18 10.87 17 97764 21455 42502099
Splenomegaly 14.16 10.87 11 97770 17036 42506518
Apgar score low 14.04 10.87 14 97767 951 42522603
Diabetes mellitus inadequate control 14.01 10.87 9 97772 15381 42508173
Infusion site discolouration 13.99 10.87 8 97773 231 42523323
Brain injury 13.98 10.87 44 97737 7611 42515943
Joint swelling 13.92 10.87 95 97686 67927 42455627
Cholelithiasis 13.86 10.87 20 97761 23326 42500228
Anion gap 13.84 10.87 13 97768 820 42522734
Thyrotoxic crisis 13.82 10.87 13 97768 821 42522733
Alopecia 13.82 10.87 29 97752 29247 42494307
Administration site pruritus 13.73 10.87 4 97777 17 42523537
Intracranial hypotension 13.72 10.87 10 97771 441 42523113
Incorrect product formulation administered 13.70 10.87 5 97776 48 42523506
Reperfusion arrhythmia 13.64 10.87 6 97775 97 42523457
Accidental death 13.64 10.87 25 97756 3058 42520496
Allergy to arthropod sting 13.56 10.87 7 97774 164 42523390
Hyperaesthesia 13.54 10.87 37 97744 5915 42517639
Iodine allergy 13.52 10.87 5 97776 50 42523504
Anterior chamber cell 13.39 10.87 10 97771 458 42523096
Postictal state 13.39 10.87 14 97767 1006 42522548
Aggression 13.35 10.87 54 97727 44109 42479445
Proteinuria 13.35 10.87 20 97761 22963 42500591
Phaeochromocytoma crisis 13.32 10.87 6 97775 103 42523451
Blood pH decreased 13.30 10.87 21 97760 2277 42521277
Swelling 13.29 10.87 188 97593 54697 42468857
Hypoaesthesia oral 13.27 10.87 32 97749 4741 42518813
Skin ulcer 13.26 10.87 24 97757 25577 42497977
Procedural pain 13.22 10.87 36 97745 5743 42517811
SARS-CoV-2 test false positive 13.20 10.87 4 97777 20 42523534
End-tidal CO2 decreased 13.17 10.87 3 97778 3 42523551
Dizziness 13.14 10.87 454 97327 248800 42274754
Product adhesion issue 13.11 10.87 18 97763 1721 42521833
Respiratory tract infection viral 13.07 10.87 26 97755 3380 42520174
Sinus bradycardia 13.07 10.87 68 97713 14785 42508769
Lung disorder 13.02 10.87 61 97720 47862 42475692
Myelodysplastic syndrome 13.01 10.87 20 97761 22725 42500829
Second primary malignancy 13.00 10.87 3 97778 9572 42513982
Foetal exposure during pregnancy 12.99 10.87 60 97721 47251 42476303
Respiratory syncytial virus infection 12.96 10.87 41 97740 7111 42516443
Posterior capsule rupture 12.88 10.87 4 97777 22 42523532
Type 2 diabetes mellitus 12.88 10.87 14 97767 18457 42505097
Liver injury 12.82 10.87 15 97766 19133 42504421
Vasculitis 12.76 10.87 14 97767 18380 42505174
Blood lactic acid increased 12.71 10.87 44 97737 7995 42515559
Accelerated idioventricular rhythm 12.70 10.87 7 97774 188 42523366
Infusion related reaction 12.67 10.87 203 97578 60603 42462951
Hepatic enzyme increased 12.60 10.87 58 97723 45726 42477828
Spinal cord oedema 12.56 10.87 8 97773 282 42523272
Skin texture abnormal 12.49 10.87 5 97776 63 42523491
Hyperphosphataemia 12.47 10.87 61 97720 12943 42510611
Erectile dysfunction 12.34 10.87 24 97757 24889 42498665
Mouth swelling 12.28 10.87 20 97761 2226 42521328
Immune reconstitution inflammatory syndrome 12.23 10.87 4 97777 10139 42513415
Poisoning deliberate 12.21 10.87 4 97777 10130 42513424
Blood lactate dehydrogenase increased 12.17 10.87 26 97755 26055 42497499
Ventricular tachyarrhythmia 12.17 10.87 9 97772 406 42523148
Atrioventricular block complete 12.13 10.87 55 97726 11309 42512245
Respiratory distress 12.11 10.87 148 97633 41672 42481882
Renal cyst 12.03 10.87 4 97777 10035 42513519
Catecholamine crisis 12.02 10.87 5 97776 70 42523484
Pneumonitis 12.00 10.87 52 97729 41666 42481888
Hepatic encephalopathy 11.98 10.87 12 97769 16430 42507124
Extrapyramidal disorder 11.93 10.87 12 97769 16400 42507154
Streptococcal infection 11.90 10.87 36 97745 6096 42517458
Red blood cell count decreased 11.89 10.87 37 97744 32678 42490876
Hallucination, auditory 11.84 10.87 10 97771 14854 42508700
Acute hepatic failure 11.83 10.87 13 97768 17060 42506494
Therapeutic product effect delayed 11.82 10.87 16 97765 1509 42522045
Pancreatitis 11.80 10.87 55 97726 43213 42480341
Foreign body 11.71 10.87 13 97768 1000 42522554
Thrombotic microangiopathy 11.70 10.87 10 97771 14772 42508782
Periorbital oedema 11.66 10.87 30 97751 4627 42518927
Cholangitis 11.64 10.87 5 97776 10722 42512832
Mucosal inflammation 11.64 10.87 66 97715 49308 42474246
Injury corneal 11.50 10.87 4 97777 33 42523521
Vertigo 11.49 10.87 125 97656 34222 42489332
Analgesic therapy 11.46 10.87 37 97744 6487 42517067
Pemphigoid 11.44 10.87 6 97775 11461 42512093
Propofol infusion syndrome 11.44 10.87 14 97767 1195 42522359
Haemophagocytic lymphohistiocytosis 11.43 10.87 15 97766 18207 42505347
Throat tightness 11.43 10.87 48 97733 9551 42514003
Epstein-Barr virus infection 11.42 10.87 4 97777 9714 42513840
Sedation 11.41 10.87 34 97747 30441 42493113
Metastases to lung 11.37 10.87 6 97775 11418 42512136
Histamine level increased 11.36 10.87 5 97776 81 42523473
Compartment syndrome 11.32 10.87 24 97757 3265 42520289
Nephrotic syndrome 11.31 10.87 3 97778 8715 42514839
Hypertonia 11.29 10.87 31 97750 4970 42518584
Dermatitis contact 11.27 10.87 29 97752 4474 42519080
Myopathy toxic 11.24 10.87 11 97770 730 42522824
Graft versus host disease 11.17 10.87 8 97773 12917 42510637
Penile vascular disorder 11.10 10.87 3 97778 9 42523545
Arteriosclerosis coronary artery 11.09 10.87 16 97765 18661 42504893
Hypercholesterolaemia 11.05 10.87 8 97773 12841 42510713
Rhabdomyolysis 11.03 10.87 120 97661 77899 42445655
Prostatic pain 11.01 10.87 8 97773 351 42523203
Lymphoma 10.96 10.87 10 97771 14311 42509243
Administration site reaction 10.93 10.87 5 97776 89 42523465
Product dose omission in error 10.92 10.87 43 97738 8311 42515243
Acute pulmonary oedema 10.88 10.87 44 97737 8607 42514947

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 1585.86 9.54 542 217576 4995 110366186
Anaphylactic reaction 1129.24 9.54 1256 216862 113044 110258137
Anaphylactic shock 924.32 9.54 786 217332 50760 110320421
Drug ineffective 879.69 9.54 5549 212569 1514991 108856190
Cardiac arrest 825.66 9.54 1430 216688 195323 110175858
Stress cardiomyopathy 812.44 9.54 461 217657 15345 110355836
Hereditary angioedema 596.45 9.54 288 217830 6826 110364355
Toxic anterior segment syndrome 516.86 9.54 210 217908 3244 110367937
Kounis syndrome 515.36 9.54 246 217872 5679 110365502
Anaesthetic complication 491.25 9.54 205 217913 3401 110367780
Hypotension 448.41 9.54 2132 215986 521717 109849464
Device failure 432.97 9.54 233 217885 6974 110364207
Synovitis 402.29 9.54 38 218080 274054 110097127
Hand deformity 369.39 9.54 14 218104 218492 110152689
Maternal exposure during delivery 353.32 9.54 162 217956 3403 110367778
Pemphigus 351.93 9.54 17 218101 214553 110156628
Chondrolysis 342.41 9.54 90 218028 287 110370894
Bradycardia 333.03 9.54 859 217259 154658 110216523
Hepatic enzyme increased 322.40 9.54 115 218003 320777 110050404
Anti-cyclic citrullinated peptide antibody positive 320.79 9.54 8 218110 181976 110189205
Pericarditis 319.85 9.54 31 218087 219083 110152098
Glossodynia 314.81 9.54 35 218083 221969 110149212
Helicobacter infection 313.20 9.54 10 218108 181867 110189314
Duodenal ulcer perforation 312.51 9.54 8 218110 177692 110193489
Joint swelling 304.13 9.54 256 217862 442589 109928592
Contraindicated product administered 304.13 9.54 60 218058 248207 110122974
Impaired quality of life 298.07 9.54 331 217787 29686 110341495
Ventricular tachycardia 293.20 9.54 424 217694 49585 110321596
General physical health deterioration 279.78 9.54 256 217862 425039 109946142
Arthropathy 277.16 9.54 110 218008 287412 110083769
Methaemoglobinaemia 263.35 9.54 185 217933 8983 110362198
Folliculitis 254.78 9.54 20 218098 167633 110203548
Cardiogenic shock 241.76 9.54 418 217700 56920 110314261
Drug intolerance 237.47 9.54 271 217847 406241 109964940
Bronchospasm 236.36 9.54 295 217823 29944 110341237
Ventricular fibrillation 235.98 9.54 346 217772 40967 110330214
Wound 232.06 9.54 86 218032 234351 110136830
Fear 227.27 9.54 254 217864 22939 110348242
Generalised tonic-clonic seizure 224.52 9.54 394 217724 54286 110316895
Drug ineffective for unapproved indication 224.18 9.54 572 217546 102266 110268915
Muscle injury 222.05 9.54 14 218104 140793 110230388
Rheumatoid factor positive 217.21 9.54 10 218108 131630 110239551
Rheumatic fever 213.72 9.54 6 218112 122573 110248608
Alopecia 209.94 9.54 246 217872 364507 110006674
Tachycardia 205.52 9.54 939 217179 225706 110145475
Accidental overdose 203.18 9.54 366 217752 51468 110319713
Pulseless electrical activity 200.42 9.54 204 217914 16553 110354628
Psoriatic arthropathy 200.14 9.54 69 218049 196692 110174489
Mobility decreased 194.92 9.54 113 218005 237309 110133872
Lagophthalmos 194.28 9.54 64 218054 520 110370661
Impaired healing 191.60 9.54 74 218044 196643 110174538
Type 2 diabetes mellitus 189.38 9.54 57 218061 177175 110194006
C-reactive protein abnormal 187.53 9.54 19 218099 129676 110241505
Renal injury 186.90 9.54 207 217911 18506 110352675
Rheumatoid arthritis 186.85 9.54 189 217929 299424 110071757
Stress 186.66 9.54 543 217575 104805 110266376
Arteriospasm coronary 186.46 9.54 150 217968 8950 110362231
Insurance issue 182.35 9.54 158 217960 10454 110360727
Shock 180.95 9.54 355 217763 53233 110317948
Emotional distress 173.65 9.54 315 217803 44532 110326649
Incorrect route of product administration 172.70 9.54 387 217731 63674 110307507
Systemic lupus erythematosus 170.84 9.54 150 217968 254188 110116993
Completed suicide 167.62 9.54 139 217979 242242 110128939
Illness 166.73 9.54 445 217673 81726 110289455
Irritable bowel syndrome 166.29 9.54 58 218060 164157 110207024
Electrocardiogram ST segment elevation 164.76 9.54 140 217978 9020 110362161
Facet joint syndrome 164.29 9.54 6 218112 96822 110274359
Lower respiratory tract infection 163.73 9.54 143 217975 242963 110128218
Liver injury 163.21 9.54 47 218071 150366 110220815
Toxicity to various agents 162.01 9.54 1552 216566 479003 109892178
Anhedonia 159.87 9.54 174 217944 15254 110355927
Dermatitis atopic 157.71 9.54 222 217896 25319 110345862
Sleep disorder due to general medical condition, insomnia type 156.65 9.54 14 218104 105629 110265552
Musculoskeletal stiffness 156.42 9.54 193 217925 279629 110091552
Accidental exposure to product 149.51 9.54 315 217803 49693 110321488
Lip dry 149.11 9.54 13 218105 100070 110271111
Therapeutic product effect decreased 147.93 9.54 158 217960 244158 110127023
Infusion site pain 147.57 9.54 177 217941 17242 110353939
Vasoplegia syndrome 147.56 9.54 106 218012 5333 110365848
Haemodynamic instability 147.39 9.54 203 217915 22685 110348496
Infusion site swelling 145.85 9.54 135 217983 9742 110361439
Sinus tachycardia 143.30 9.54 289 217829 44204 110326977
Inspiratory capacity decreased 136.88 9.54 77 218041 2518 110368663
Peripheral venous disease 136.81 9.54 7 218111 84110 110287071
Unresponsive to stimuli 136.08 9.54 352 217766 63438 110307743
Corneal oedema 135.24 9.54 82 218036 3091 110368090
Endophthalmitis 134.86 9.54 119 217999 8068 110363113
Swollen joint count increased 132.85 9.54 8 218110 83653 110287528
Seizure 132.19 9.54 817 217301 220368 110150813
Inflammation 132.14 9.54 112 218006 193126 110178055
Cauda equina syndrome 131.38 9.54 70 218048 2052 110369129
Infusion site erythema 129.40 9.54 138 217980 11821 110359360
Pulse absent 128.77 9.54 134 217984 11158 110360023
Swollen tongue 126.62 9.54 331 217787 60031 110311150
COVID-19 126.23 9.54 872 217246 244188 110126993
Diarrhoea 125.71 9.54 1542 216576 1137963 109233218
No adverse event 124.49 9.54 374 217744 73465 110297716
Unevaluable event 124.47 9.54 325 217793 58902 110312279
Decreased appetite 123.49 9.54 501 217617 475345 109895836
Bursitis 123.01 9.54 51 218067 129867 110241314
Hypercholesterolaemia 122.18 9.54 17 218101 90820 110280361
Stomatitis 120.33 9.54 218 217900 270024 110101157
Anaesthetic complication neurological 118.50 9.54 52 218066 981 110370200
Sinusitis 115.04 9.54 988 217130 295700 110075481
Asthenia 111.64 9.54 848 217270 688151 109683030
Ill-defined disorder 110.85 9.54 88 218030 156765 110214416
Overdose 109.44 9.54 813 217305 232981 110138200
Injection site pallor 109.25 9.54 26 218092 47 110371134
Wrong product administered 107.32 9.54 120 217998 10840 110360341
Infusion site extravasation 106.49 9.54 123 217995 11511 110359670
Left ventricle outflow tract obstruction 105.89 9.54 40 218078 503 110370678
Abdominal discomfort 105.76 9.54 409 217709 393449 109977732
Liver disorder 105.39 9.54 76 218042 142167 110229014
Injury associated with device 104.35 9.54 79 218039 4310 110366871
Urticaria 103.00 9.54 1021 217097 317836 110053345
Neutropenia 101.24 9.54 388 217730 374232 109996949
Rhinitis 101.15 9.54 169 217949 22376 110348805
Gait inability 100.86 9.54 73 218045 136303 110234878
Electrocardiogram QRS complex prolonged 100.11 9.54 126 217992 12895 110358286
Angioedema 99.75 9.54 422 217696 98078 110273103
Stridor 99.42 9.54 93 218025 6802 110364379
Fibromyalgia 98.53 9.54 115 218003 170794 110200387
Blister 98.05 9.54 187 217931 227189 110143992
Circulatory collapse 97.69 9.54 243 217875 42750 110328431
Osteoarthritis 96.81 9.54 131 217987 182492 110188689
Loss of consciousness 96.08 9.54 690 217428 195616 110175565
Arthralgia 95.54 9.54 1030 217088 778602 109592579
Hypopnoea 95.36 9.54 115 218003 11265 110359916
Infusion related reaction 95.30 9.54 407 217711 380755 109990426
Infusion site pruritus 95.15 9.54 79 218039 4929 110366252
Grip strength decreased 94.78 9.54 21 218097 80153 110291028
Procedural hypotension 94.76 9.54 60 218058 2445 110368736
Catarrh 94.53 9.54 93 218025 7242 110363939
Blood cholesterol increased 94.51 9.54 136 217982 184649 110186532
C-reactive protein increased 94.16 9.54 179 217939 217740 110153441
Burns second degree 94.04 9.54 95 218023 7638 110363543
Metabolic acidosis 93.87 9.54 418 217700 99326 110271855
Pulmonary fibrosis 93.51 9.54 42 218076 102000 110269181
Joint range of motion decreased 93.03 9.54 63 218055 121769 110249412
Inappropriate schedule of product administration 92.39 9.54 703 217415 202934 110168247
Deep vein thrombosis postoperative 90.26 9.54 7 218111 59284 110311897
Hypoxia 90.04 9.54 498 217620 129017 110242164
Musculoskeletal pain 89.44 9.54 139 217979 182884 110188297
Thrombocytopenia 88.78 9.54 370 217748 348515 110022666
Needle issue 88.55 9.54 140 217978 17700 110353481
Product dose omission issue 88.27 9.54 997 217121 320785 110050396
Injection site ischaemia 87.55 9.54 18 218100 8 110371173
Seasonal allergy 86.03 9.54 146 217972 19576 110351605
Obesity 86.03 9.54 59 218059 113292 110257889
Pulmonary oedema 85.24 9.54 409 217709 100250 110270931
Apnoea 84.87 9.54 119 217999 13520 110357661
Multiple organ dysfunction syndrome 84.17 9.54 550 217568 151160 110220021
Hyperthermia malignant 83.57 9.54 66 218052 3834 110367347
Electrocardiogram ST segment depression 83.28 9.54 76 218042 5385 110365796
Drug-induced liver injury 82.79 9.54 69 218049 119998 110251183
Abdominal pain upper 82.30 9.54 381 217737 348730 110022451
Infusion site haemorrhage 82.13 9.54 70 218048 4528 110366653
Post procedural complication 82.10 9.54 170 217948 26488 110344693
Interstitial lung disease 81.12 9.54 93 218025 139241 110231940
Status epilepticus 80.94 9.54 187 217931 31384 110339797
Steroid dependence 79.98 9.54 91 218027 8378 110362803
Expired product administered 79.60 9.54 90 218028 8230 110362951
Lung disorder 79.44 9.54 146 217972 179901 110191280
Disease progression 79.42 9.54 233 217885 243801 110127380
Acute kidney injury 79.19 9.54 836 217282 634594 109736587
Hyperaesthesia 77.88 9.54 119 217999 14608 110356573
Blood pressure decreased 77.65 9.54 439 217679 114652 110256529
Gastrointestinal disorder 77.30 9.54 233 217885 241719 110129462
Parosmia 76.14 9.54 111 218007 13069 110358112
Respiratory depression 76.02 9.54 184 217934 31817 110339364
Infusion site bruising 75.91 9.54 61 218057 3633 110367548
Nail disorder 75.25 9.54 12 218106 57923 110313258
Asthma 74.84 9.54 789 217329 249502 110121679
Injection site laceration 73.98 9.54 22 218096 122 110371059
Wound infection 73.49 9.54 50 218068 96415 110274766
Multiple allergies 73.36 9.54 105 218013 12158 110359023
Prescribed underdose 73.25 9.54 19 218099 65155 110306026
Hypoaesthesia oral 73.02 9.54 125 217993 16877 110354304
Tryptase increased 72.53 9.54 36 218082 907 110370274
Adverse event 72.02 9.54 65 218053 108744 110262437
Lip swelling 72.02 9.54 242 217876 50425 110320756
Pancytopenia 72.00 9.54 195 217923 209418 110161763
Upper respiratory tract infection 71.56 9.54 474 217644 130854 110240327
Accidental exposure to product by child 70.42 9.54 55 218063 3143 110368038
Hypoxic-ischaemic encephalopathy 70.24 9.54 87 218031 8760 110362421
Night sweats 70.11 9.54 97 218021 133886 110237295
Lower limb fracture 69.06 9.54 31 218087 75317 110295864
Bronchitis 68.92 9.54 538 217580 156494 110214687
Hypopyon 68.64 9.54 40 218078 1400 110369781
Cyanosis 68.52 9.54 169 217949 29572 110341609
Sulphaemoglobinaemia 68.41 9.54 30 218088 565 110370616
Mydriasis 67.89 9.54 141 217977 22016 110349165
Onychomadesis 67.83 9.54 6 218112 45657 110325524
Cardiac output increased 67.65 9.54 30 218088 581 110370600
Adjustment disorder with depressed mood 67.31 9.54 5 218113 43878 110327303
Treatment failure 66.85 9.54 300 217818 276934 110094247
Systolic anterior motion of mitral valve 66.55 9.54 18 218100 66 110371115
Myelosuppression 66.55 9.54 53 218065 94287 110276894
Retinal artery occlusion 66.49 9.54 60 218058 4189 110366992
Malignant neoplasm progression 66.48 9.54 154 217964 174413 110196768
Body tinea 66.20 9.54 45 218073 2070 110369111
Blepharospasm 65.58 9.54 14 218104 54837 110316344
Blood lactic acid decreased 65.52 9.54 29 218089 559 110370622
Eczema 64.31 9.54 298 217820 71995 110299186
Embolia cutis medicamentosa 63.12 9.54 33 218085 930 110370251
Peripheral swelling 63.11 9.54 502 217616 403532 109967649
Respiratory acidosis 62.50 9.54 104 218014 13722 110357459
Phrenic nerve paralysis 62.36 9.54 28 218090 559 110370622
Cardiotoxicity 62.10 9.54 116 218002 16765 110354416
Infusion site mass 61.92 9.54 40 218078 1688 110369493
Trigemino-cardiac reflex 61.56 9.54 26 218092 445 110370736
Injection site pain 61.47 9.54 578 217540 177344 110193837
Paraplegia 60.91 9.54 68 218050 6132 110365049
Impaired work ability 60.73 9.54 150 217968 26269 110344912
Psoriasis 60.45 9.54 115 218003 139878 110231303
Product quality issue 60.40 9.54 307 217811 76992 110294189
Incorrect drug administration rate 60.37 9.54 64 218054 5444 110365737
Gingival pain 60.24 9.54 110 218008 15626 110355555
Airway peak pressure increased 59.84 9.54 28 218090 617 110370564
Hepatic cirrhosis 58.65 9.54 30 218088 67596 110303585
Anaemia 58.31 9.54 745 217373 546341 109824840
Tracheal deviation 58.28 9.54 22 218096 276 110370905
Coeliac disease 58.27 9.54 8 218110 43179 110328002
Vitamin B1 decreased 58.20 9.54 31 218087 908 110370273
Peripheral ischaemia 57.98 9.54 89 218029 10969 110360212
Pharyngeal swelling 57.76 9.54 93 218025 11939 110359242
Oedema peripheral 57.71 9.54 395 217723 328265 110042916
Leukopenia 57.68 9.54 130 217988 148661 110222520
Confusional state 56.57 9.54 621 217497 468059 109903122
Respiratory tract infection 56.35 9.54 285 217833 71332 110299849
Spinal cord infarction 56.35 9.54 32 218086 1066 110370115
Paralysis 55.90 9.54 106 218012 15494 110355687
Hepatitis 55.87 9.54 57 218061 89997 110281184
Cholestasis 55.39 9.54 29 218089 64489 110306692
Tinnitus 54.92 9.54 251 217867 60289 110310892
Swelling 54.42 9.54 437 217681 350604 110020577
Lupus-like syndrome 54.00 9.54 8 218110 40784 110330397
Injection site coldness 53.93 9.54 17 218101 118 110371063
Removal of foreign body 53.77 9.54 13 218105 26 110371155
Injection site injury 53.51 9.54 31 218087 1073 110370108
Respiratory distress 52.74 9.54 272 217846 68602 110302579
Dermatitis contact 52.73 9.54 97 218021 13856 110357325
Cataract operation complication 52.00 9.54 20 218098 265 110370916
Hip arthroplasty 51.09 9.54 23 218095 55790 110315391
Epilepsy 50.98 9.54 74 218044 100135 110271046
Oxygen saturation decreased 50.30 9.54 502 217616 156480 110214701
Sciatica 50.26 9.54 65 218053 92334 110278847
Infusion site discharge 50.22 9.54 37 218081 1936 110369245
Blood lactic acid increased 50.03 9.54 102 218016 15719 110355462
Neuromuscular block prolonged 50.02 9.54 31 218087 1216 110369965
Ventricular arrhythmia 49.84 9.54 79 218039 10008 110361173
Throat tightness 49.41 9.54 162 217956 33327 110337854
Ventricular extrasystoles 49.37 9.54 126 217992 22515 110348666
Heart rate increased 49.05 9.54 466 217652 143368 110227813
Coagulation factor deficiency 49.04 9.54 20 218098 312 110370869
Laryngeal oedema 48.73 9.54 77 218041 9730 110361451
Distributive shock 48.39 9.54 59 218059 5845 110365336
Anterior chamber cell 48.08 9.54 30 218088 1191 110369990
Red blood cell sedimentation rate increased 48.07 9.54 50 218068 78252 110292929
Poor venous access 47.91 9.54 131 217987 24391 110346790
Knee arthroplasty 47.71 9.54 35 218083 64913 110306268
Mean arterial pressure decreased 47.68 9.54 22 218096 469 110370712
Ophthalmoplegia 47.60 9.54 46 218072 3504 110367677
Dyspepsia 47.01 9.54 205 217913 190760 110180421
Erythema 46.62 9.54 821 217297 290626 110080555
Anxiety 46.25 9.54 946 217172 344132 110027049
Type I hypersensitivity 46.21 9.54 60 218058 6333 110364848
Procedural complication 45.98 9.54 69 218049 8336 110362845
Myocardial ischaemia 45.76 9.54 136 217982 26548 110344633
Orthostatic hypotension 45.75 9.54 38 218080 66211 110304970
Blood pH decreased 45.51 9.54 51 218067 4618 110366563
Vitamin B1 increased 45.29 9.54 16 218102 164 110371017
SARS-CoV-2 test negative 45.20 9.54 36 218082 2117 110369064
Extradural abscess 44.83 9.54 35 218083 1999 110369182
Ear infection 44.11 9.54 242 217876 62490 110308691
Systemic toxicity 44.06 9.54 19 218099 343 110370838
Intentional self-injury 43.84 9.54 10 218108 37419 110333762
Meningitis chemical 43.66 9.54 19 218099 351 110370830
Anaphylactoid shock 43.36 9.54 26 218092 960 110370221
Vasospasm 43.06 9.54 31 218087 1565 110369616
Foot deformity 42.80 9.54 21 218097 48459 110322722
Coagulation factor V level abnormal 42.70 9.54 15 218103 151 110371030
Vitritis 42.58 9.54 38 218080 2615 110368566
Anal inflammation 42.56 9.54 37 218081 2459 110368722
Status asthmaticus 42.53 9.54 26 218092 995 110370186
C-reactive protein 42.42 9.54 5 218113 30326 110340855
Breast cancer stage II 42.33 9.54 3 218115 27372 110343809
Product adhesion issue 42.29 9.54 40 218078 2966 110368215
Delayed recovery from anaesthesia 42.20 9.54 35 218083 2180 110369001
Eyelid rash 42.12 9.54 20 218098 456 110370725
Dry mouth 42.05 9.54 227 217891 199721 110171460
Onychomycosis 41.86 9.54 12 218106 38519 110332662
Device use issue 41.53 9.54 44 218074 3740 110367441
Factor V Leiden mutation 41.23 9.54 17 218101 273 110370908
Memory impairment 41.19 9.54 224 217894 196720 110174461
Ventricular hypokinesia 41.18 9.54 77 218041 11137 110360044
Autoimmune disorder 41.13 9.54 41 218077 65442 110305739
Alcohol poisoning 40.97 9.54 68 218050 8952 110362229
Hyperdynamic left ventricle 40.85 9.54 21 218097 571 110370610
Underdose 40.83 9.54 39 218079 63515 110307666
Infusion site urticaria 40.77 9.54 27 218091 1189 110369992
Liquid product physical issue 40.72 9.54 30 218088 1570 110369611
Pharyngeal oedema 40.68 9.54 96 218022 16332 110354849
Drug reaction with eosinophilia and systemic symptoms 40.42 9.54 62 218056 82033 110289148
Extradural haematoma 40.26 9.54 41 218077 3328 110367853
Product use in unapproved indication 39.33 9.54 1158 216960 446219 109924962
Cytomegalovirus infection 39.14 9.54 30 218088 54414 110316767
Vocal cord dysfunction 39.08 9.54 24 218094 926 110370255
Prescribed overdose 38.64 9.54 71 218047 87510 110283671
Mental status changes 38.63 9.54 270 217848 75852 110295329
Respiratory arrest 38.40 9.54 221 217897 58078 110313103
Hyperlactacidaemia 38.36 9.54 63 218055 8223 110362958
Cardio-respiratory arrest 37.87 9.54 372 217746 115464 110255717
Infection susceptibility increased 37.76 9.54 45 218073 4353 110366828
Taste disorder 37.67 9.54 44 218074 65343 110305838
Paranasal cyst 37.60 9.54 23 218095 881 110370300
Premature delivery 37.25 9.54 139 217979 30493 110340688
Vascular malformation 37.19 9.54 22 218096 792 110370389
Brain oedema 36.89 9.54 140 217978 30958 110340223
Medical device site laceration 36.61 9.54 7 218111 0 110371181
Product administration error 36.55 9.54 158 217960 37059 110334122
Therapeutic product effect incomplete 36.35 9.54 275 217843 223530 110147651
Hepatotoxicity 36.16 9.54 43 218075 63357 110307824
Compartment syndrome 35.93 9.54 51 218067 5859 110365322
Chills 35.69 9.54 551 217567 190029 110181152
Back injury 35.52 9.54 25 218093 47374 110323807
Aqueous fibrin 35.45 9.54 14 218104 200 110370981
Cardiac failure congestive 35.42 9.54 165 217953 150835 110220346
Ischaemia 35.41 9.54 64 218054 9019 110362162
PCO2 increased 35.11 9.54 30 218088 1947 110369234
Quadriplegia 35.06 9.54 42 218076 4085 110367096
Product distribution issue 34.92 9.54 43 218075 4303 110366878
Insomnia 34.78 9.54 501 217617 360089 110011092
Procedural haemorrhage 34.74 9.54 48 218070 5379 110365802
Chondromalacia 34.59 9.54 13 218105 161 110371020
Troponin I increased 34.57 9.54 48 218070 5404 110365777
Infusion site rash 34.55 9.54 32 218086 2311 110368870
Bladder prolapse 34.38 9.54 26 218092 1416 110369765
Purtscher retinopathy 34.18 9.54 14 218104 221 110370960
Dry gangrene 34.17 9.54 23 218095 1041 110370140
Myopathy toxic 34.07 9.54 25 218093 1300 110369881
Malaise 34.05 9.54 1037 217081 670782 109700399
Sinus bradycardia 33.56 9.54 131 217987 29352 110341829
Drug resistance 33.49 9.54 37 218081 56337 110314844
Seizure like phenomena 33.43 9.54 32 218086 2409 110368772
Pharyngitis streptococcal 33.33 9.54 78 218040 13199 110357982
Infection 33.28 9.54 508 217610 361692 110009489
Agranulocytosis 33.02 9.54 44 218074 61716 110309465
Hypercapnia 33.01 9.54 70 218048 11089 110360092
Drug tolerance decreased 32.98 9.54 7 218111 27533 110343648
Sleep disorder 32.77 9.54 243 217875 198401 110172780
Nerve root injury 32.69 9.54 10 218108 62 110371119
Hepatocellular injury 32.62 9.54 31 218087 50611 110320570
Brain injury 32.56 9.54 78 218040 13398 110357783
Neurotoxicity 32.53 9.54 167 217951 42040 110329141
Intentional product use issue 32.51 9.54 322 217796 247584 110123597
Incorrect dose administered 32.50 9.54 330 217788 103311 110267870
Adulterated product 32.46 9.54 23 218095 1132 110370049
Injection site hypoaesthesia 32.43 9.54 19 218099 672 110370509
Exostosis 32.18 9.54 26 218092 45930 110325251
Staphylococcal infection 31.99 9.54 242 217876 69702 110301479
Fear of eating 31.52 9.54 17 218101 511 110370670
Uterine hypertonus 31.34 9.54 14 218104 276 110370905
Nystagmus 31.26 9.54 70 218048 11507 110359674
Visual acuity reduced 31.14 9.54 136 217982 32037 110339144
Neuromuscular blockade 31.13 9.54 19 218099 725 110370456
Gastroenteritis viral 30.99 9.54 133 217985 31093 110340088
Cardiac murmur 30.99 9.54 113 218005 24515 110346666
Hepatic cytolysis 30.70 9.54 38 218080 55015 110316166
Inhibitory drug interaction 30.54 9.54 43 218075 4904 110366277
Diabetes insipidus 30.48 9.54 50 218068 6520 110364661
Product use issue 30.43 9.54 432 217686 311263 110059918
Peripheral nerve injury 30.29 9.54 22 218096 1126 110370055
Injection site inflammation 30.24 9.54 42 218076 4729 110366452
Metastases to liver 30.23 9.54 16 218102 35370 110335811
Sinobronchitis 30.12 9.54 16 218102 466 110370715
Lung hyperinflation 30.11 9.54 29 218089 2200 110368981
Hyponatraemia 29.68 9.54 280 217838 217373 110153808
Oropharyngeal pain 29.64 9.54 402 217716 134874 110236307
Hypercalcaemia 29.54 9.54 29 218089 46628 110324553
Sinus arrest 29.40 9.54 39 218079 4203 110366978
Paraesthesia oral 29.36 9.54 138 217980 33533 110337648
Pancreatitis acute 29.22 9.54 46 218072 60228 110310953
Respiratory failure 29.05 9.54 591 217527 214741 110156440
Harlequin syndrome 29.02 9.54 13 218105 258 110370923
Product contamination microbial 28.94 9.54 21 218097 1073 110370108
Jaundice 28.91 9.54 45 218073 59191 110311990
Gas gangrene 28.90 9.54 14 218104 334 110370847
White blood cell count decreased 28.82 9.54 301 217817 229089 110142092
Influenza 28.69 9.54 481 217637 168620 110202561
Swelling face 28.49 9.54 293 217825 92028 110279153
Joint stiffness 28.36 9.54 56 218062 67187 110303994
Intentional overdose 28.31 9.54 392 217726 132109 110239072
Glucose tolerance impaired 28.28 9.54 61 218057 9776 110361405
Supraventricular tachycardia 28.19 9.54 109 218009 24313 110346868
Nasal discharge discolouration 27.89 9.54 33 218085 3168 110368013
Pupil fixed 27.71 9.54 36 218082 3802 110367379
Coma 27.37 9.54 354 217764 117515 110253666
Upper airway obstruction 27.32 9.54 25 218093 1777 110369404
Pallor 27.32 9.54 198 217920 56269 110314912
Schizophrenia 27.29 9.54 5 218113 21821 110349360
Brain stem syndrome 27.28 9.54 22 218096 1317 110369864
Proctalgia 27.20 9.54 72 218046 13150 110358031
Liver function test increased 27.04 9.54 87 218031 88461 110282720
Neuralgia 27.02 9.54 176 217942 48302 110322879
Gait disturbance 27.00 9.54 386 217732 277822 110093359
Miosis 26.93 9.54 100 218018 21883 110349298
Polyarthritis 26.84 9.54 3 218115 18960 110352221
Eye infection 26.83 9.54 76 218042 14442 110356739
Rheumatoid nodule 26.82 9.54 4 218114 20292 110350889
Blood phosphorus increased 26.81 9.54 82 218036 16258 110354923
Chest discomfort 26.81 9.54 487 217631 173361 110197820
Finger deformity 26.78 9.54 16 218102 33076 110338105
Melaena 26.70 9.54 60 218058 68697 110302484
Anaphylactoid reaction 26.49 9.54 48 218070 6778 110364403
Bronchiectasis 26.48 9.54 142 217976 36351 110334830
Retinal vasculitis 26.44 9.54 26 218092 2023 110369158
Extremity necrosis 26.42 9.54 35 218083 3767 110367414
Anal sphincter atony 26.40 9.54 15 218103 500 110370681
Post cholecystectomy syndrome 26.37 9.54 18 218100 834 110370347
Product preparation error 26.32 9.54 63 218055 10816 110360365
Torsade de pointes 26.20 9.54 101 218017 22499 110348682
Diabetes mellitus inadequate control 26.13 9.54 13 218105 29762 110341419
Electrocardiogram T wave inversion 26.04 9.54 43 218075 5637 110365544
Myocardial stunning 25.99 9.54 13 218105 333 110370848
Acute pulmonary oedema 25.78 9.54 83 218035 16913 110354268
Pregnancy 25.69 9.54 38 218080 51029 110320152
Platelet aggregation inhibition 25.49 9.54 11 218107 199 110370982
Corneal reflex decreased 25.41 9.54 15 218103 538 110370643
Electrocardiogram abnormal 25.39 9.54 88 218030 18621 110352560
Liver function test abnormal 25.31 9.54 62 218056 68888 110302293
Disease recurrence 25.31 9.54 51 218067 60733 110310448
Creatinine renal clearance decreased 25.21 9.54 6 218112 21809 110349372
Poor quality sleep 25.16 9.54 116 218002 27961 110343220
Laryngospasm 25.08 9.54 38 218080 4630 110366551
Monoplegia 25.02 9.54 39 218079 4870 110366311
Viral infection 24.95 9.54 185 217933 52954 110318227
Propofol infusion syndrome 24.76 9.54 28 218090 2561 110368620
Mast cell activation syndrome 24.75 9.54 22 218096 1506 110369675
Spinal cord oedema 24.72 9.54 14 218104 464 110370717
Medication error 24.70 9.54 317 217801 105049 110266132
Weight increased 24.49 9.54 635 217483 419009 109952172
Pneumocystis jirovecii pneumonia 24.35 9.54 29 218089 42706 110328475
Hypoglycaemia 24.30 9.54 132 217986 115972 110255209
Lactic acidosis 24.25 9.54 285 217833 92526 110278655
Vasoconstriction 24.25 9.54 19 218099 1091 110370090
Road traffic accident 24.22 9.54 119 217999 107279 110263902
Macular ischaemia 24.03 9.54 11 218107 230 110370951
International normalised ratio increased 23.96 9.54 89 218029 86683 110284498
Accident 23.93 9.54 61 218057 10891 110360290
Mean arterial pressure increased 23.91 9.54 9 218109 112 110371069
Medical device entrapment 23.90 9.54 6 218112 15 110371166
Eyelid ptosis 23.88 9.54 69 218049 13258 110357923
Death 23.81 9.54 1131 216987 697738 109673443
Spinal anaesthesia 23.62 9.54 9 218109 116 110371065
Chemical burn 23.62 9.54 16 218102 732 110370449
Bundle branch block left 23.36 9.54 67 218051 12821 110358360
Spinal epidural haemorrhage 23.35 9.54 12 218106 326 110370855
Haemorrhoids 23.35 9.54 135 217983 35537 110335644
Abdominal pain 23.30 9.54 803 217315 512186 109858995
Infusion site irritation 23.29 9.54 19 218099 1156 110370025
Oral herpes 23.26 9.54 136 217982 35944 110335237
Abortion spontaneous 23.26 9.54 20 218098 34262 110336919
Throat irritation 23.22 9.54 183 217935 53369 110317812
Oculocardiac reflex 23.21 9.54 9 218109 122 110371059
Infusion site discomfort 23.13 9.54 23 218095 1814 110369367
Food allergy 23 9.54 89 218029 19859 110351322
Myocardial calcification 23.00 9.54 11 218107 255 110370926
Postoperative delirium 22.93 9.54 17 218101 898 110370283
Nerve block 22.84 9.54 16 218102 773 110370408
Blindness 22.76 9.54 136 217982 36223 110334958
Atrioventricular block complete 22.67 9.54 89 218029 19993 110351188
Muscle spasms 22.61 9.54 399 217719 277758 110093423
Blood creatinine increased 22.56 9.54 241 217877 182648 110188533
Diplegia 22.38 9.54 25 218093 2256 110368925
Arthritis bacterial 22.34 9.54 59 218059 10761 110360420
Central pain syndrome 22.29 9.54 16 218102 804 110370377
Device ineffective 22.21 9.54 10 218108 201 110370980
Negative pressure pulmonary oedema 22.18 9.54 15 218103 684 110370497
Catheter site pain 22.11 9.54 43 218075 6403 110364778
Acute respiratory distress syndrome 22.09 9.54 180 217938 53018 110318163
Eye inflammation 22.07 9.54 53 218065 9118 110362063
Prostate cancer 22.04 9.54 25 218093 37616 110333565
Accelerated idioventricular rhythm 22.02 9.54 11 218107 281 110370900
Electrocardiogram ST segment abnormal 21.83 9.54 22 218096 1763 110369418
Limb injury 21.81 9.54 138 217980 37498 110333683
Neuroleptic malignant syndrome 21.76 9.54 21 218097 34038 110337143
Pemphigoid 21.66 9.54 6 218112 19701 110351480
Rectal prolapse 21.64 9.54 26 218092 2537 110368644
Pneumocephalus 21.56 9.54 13 218105 485 110370696
Discomfort 21.50 9.54 296 217822 214411 110156770
Gastrooesophageal reflux disease 21.46 9.54 239 217879 179737 110191444
Urinary tract infection 21.35 9.54 816 217302 325466 110045715
Mastoiditis 21.25 9.54 26 218092 2585 110368596
Bone marrow failure 21.24 9.54 52 218066 57796 110313385
Hyperlipidaemia 21.12 9.54 132 217986 35716 110335465
Device infusion issue 21.11 9.54 28 218090 3017 110368164
Osteonecrosis of jaw 21.11 9.54 39 218079 47978 110323203
Otitis media 21.08 9.54 46 218072 7430 110363751
Laboratory test abnormal 21.02 9.54 34 218084 44045 110327136
Oropharyngeal discomfort 21.01 9.54 56 218062 10271 110360910
Foetal heart rate decreased 20.92 9.54 7 218111 60 110371121
Amnesia 20.89 9.54 122 217996 105286 110265895
Myasthenia gravis 20.87 9.54 91 218027 21420 110349761
Eye irritation 20.86 9.54 125 217993 33327 110337854
Hypoventilation 20.86 9.54 48 218070 8033 110363148
Spinal stroke 20.82 9.54 7 218111 61 110371120
Arterial spasm 20.79 9.54 9 218109 164 110371017
Haemoglobin decreased 20.79 9.54 355 217763 248372 110122809
Corneal epithelium defect 20.77 9.54 16 218102 896 110370285
Ventricular tachyarrhythmia 20.75 9.54 13 218105 520 110370661
Disseminated intravascular coagulation 20.68 9.54 146 217972 41140 110330041
Tracheitis 20.67 9.54 21 218097 1700 110369481
Gastrointestinal haemorrhage 20.45 9.54 218 217900 165300 110205881
Blood immunoglobulin A increased 20.43 9.54 20 218098 1548 110369633
Glomerular filtration rate increased 20.26 9.54 22 218096 1923 110369258
Corneal opacity 20.24 9.54 18 218100 1233 110369948
Apnoeic attack 20.16 9.54 15 218103 797 110370384
Coronary artery disease 20.15 9.54 73 218045 71617 110299564
Lymphopenia 20.10 9.54 30 218088 40140 110331041
Inadequate analgesia 20.08 9.54 36 218082 5041 110366140
Allergic sinusitis 20.06 9.54 21 218097 1760 110369421
Constipation 19.92 9.54 545 217573 357241 110013940
Familial periodic paralysis 19.88 9.54 11 218107 348 110370833
Mastocytosis 19.83 9.54 15 218103 817 110370364
Cough 19.72 9.54 1106 217012 460535 109910646
Analgesic therapy 19.62 9.54 44 218074 7240 110363941
Electric shock 19.61 9.54 21 218097 1807 110369374
Fatigue 19.57 9.54 2100 216018 1213858 109157323
BRASH syndrome 19.57 9.54 30 218088 3693 110367488
Respiratory tract infection bacterial 19.57 9.54 24 218094 2392 110368789
Meningitis aseptic 19.55 9.54 53 218065 9817 110361364
Trigeminal palsy 19.54 9.54 7 218111 75 110371106
Cardiovascular insufficiency 19.44 9.54 28 218090 3260 110367921
Fear of death 19.40 9.54 20 218098 1647 110369534
Heparin-induced thrombocytopenia 19.38 9.54 58 218060 11366 110359815
Fluid retention 19.31 9.54 108 218010 94199 110276982
Electrocardiogram QT prolonged 19.24 9.54 312 217806 108648 110262533
Pupillary reflex impaired 19.23 9.54 31 218087 3984 110367197
Spinal meningeal cyst 19.21 9.54 8 218110 132 110371049
Walking aid user 19.09 9.54 13 218105 25062 110346119
Post-traumatic stress disorder 19.08 9.54 41 218077 6555 110364626
Jaundice cholestatic 19.03 9.54 3 218115 14605 110356576
PO2 decreased 18.90 9.54 27 218091 3121 110368060
Spinal epidural haematoma 18.83 9.54 20 218098 1705 110369476
Hyperphosphataemia 18.82 9.54 73 218045 16308 110354873
Soft tissue atrophy 18.75 9.54 6 218112 44 110371137
Administration site swelling 18.75 9.54 13 218105 618 110370563
Neoplasm progression 18.67 9.54 65 218053 64530 110306651
Phaeochromocytoma crisis 18.67 9.54 12 218106 502 110370679
Post transplant lymphoproliferative disorder 18.63 9.54 4 218114 15609 110355572
Dactylitis 18.56 9.54 31 218087 4102 110367079
Injection site swelling 18.54 9.54 195 217923 61595 110309586
Flushing 18.53 9.54 300 217818 104436 110266745
Drug therapy 18.48 9.54 43 218075 7248 110363933
Epidural haemorrhage 18.45 9.54 11 218107 402 110370779
Oedema 18.43 9.54 297 217821 209679 110161502
Deafness permanent 18.34 9.54 15 218103 916 110370265
End-tidal CO2 decreased 18.32 9.54 7 218111 91 110371090
Open globe injury 18.31 9.54 9 218109 222 110370959
Medical device site cellulitis 18.31 9.54 9 218109 222 110370959
Axillary nerve injury 18.29 9.54 6 218112 48 110371133
Sedation 18.26 9.54 73 218045 69610 110301571
Lung neoplasm malignant 18.20 9.54 24 218094 33818 110337363
Streptococcal infection 18.20 9.54 55 218063 10835 110360346
Blood pressure increased 18.07 9.54 651 217467 257722 110113459
Incorrect product formulation administered 18.05 9.54 9 218109 229 110370952
Skin infection 18.00 9.54 90 218028 22419 110348762
Product confusion 17.98 9.54 9 218109 231 110370950
Autonomic nervous system imbalance 17.96 9.54 37 218081 5743 110365438
Muscle tightness 17.96 9.54 67 218051 14695 110356486
Infusion site nodule 17.87 9.54 11 218107 426 110370755
Burning sensation 17.84 9.54 212 217906 69000 110302181
Rotator cuff syndrome 17.81 9.54 73 218045 16721 110354460
Airway complication of anaesthesia 17.80 9.54 13 218105 671 110370510
Sleep disorder therapy 17.79 9.54 43 218075 7428 110363753
Capillary nail refill test abnormal 17.79 9.54 7 218111 99 110371082
Skin ulcer 17.76 9.54 65 218053 63580 110307601
Diabetic ketoacidosis 17.76 9.54 35 218083 42023 110329158
Vertigo 17.75 9.54 255 217863 86615 110284566
Vasculitis 17.75 9.54 27 218091 35846 110335335
Bursitis infective 17.70 9.54 18 218100 1458 110369723
Administration site pain 17.67 9.54 14 218104 817 110370364
Peritonitis 17.67 9.54 23 218095 32584 110338597
Anterior chamber fibrin 17.63 9.54 9 218109 241 110370940
Tremor 17.61 9.54 523 217595 201709 110169472
Scar 17.61 9.54 73 218045 16808 110354373
Bladder cancer 17.60 9.54 9 218109 20283 110350898
Appendicolith 17.59 9.54 65 218053 14190 110356991
Epidural analgesia 17.58 9.54 8 218110 165 110371016
Chronic kidney disease 17.51 9.54 84 218034 76207 110294974
Gamma-glutamyltransferase increased 17.51 9.54 62 218056 61247 110309934
Cardiac index decreased 17.45 9.54 8 218110 168 110371013
Product dose omission in error 17.40 9.54 92 218026 23420 110347761
Pancreatic carcinoma 17.36 9.54 4 218114 14868 110356313
Anaesthetic complication pulmonary 17.36 9.54 8 218110 170 110371011
Tracheobronchitis 17.35 9.54 24 218094 2692 110368489
Procedure aborted 17.23 9.54 8 218110 173 110371008
Eye swelling 17.22 9.54 118 218000 32930 110338251
Inappropriate antidiuretic hormone secretion 17.21 9.54 25 218093 33826 110337355
Nodal rhythm 17.18 9.54 27 218091 3396 110367785
Respiratory tract congestion 17.18 9.54 112 218006 30745 110340436
Skin discomfort 17.15 9.54 21 218097 2089 110369092
SARS-CoV-2 test false positive 17.08 9.54 5 218113 26 110371155
Palpitations 17.07 9.54 423 217695 158789 110212392
Blood creatine phosphokinase increased 17.05 9.54 80 218038 72997 110298184
Vocal cord disorder 17.01 9.54 19 218099 1714 110369467
Foreign body 16.98 9.54 25 218093 2970 110368211
Product preparation issue 16.92 9.54 24 218094 2755 110368426
Polyneuropathy 16.92 9.54 23 218095 31989 110339192
Punctate keratitis 16.90 9.54 16 218102 1188 110369993
Croup infectious 16.77 9.54 15 218103 1035 110370146
Eyelid oedema 16.71 9.54 67 218051 15195 110355986
Troponin increased 16.55 9.54 108 218010 29658 110341523
Phrenic nerve injury 16.54 9.54 4 218114 8 110371173
Injection site atrophy 16.54 9.54 11 218107 488 110370693
Glossoptosis 16.52 9.54 9 218109 276 110370905
Retinal vascular occlusion 16.49 9.54 12 218106 616 110370565
Laryngitis 16.47 9.54 37 218081 42374 110328807
Nasal congestion 16.46 9.54 279 217839 98003 110273178
Laryngeal obstruction 16.46 9.54 7 218111 122 110371059
Spinal cord compression 16.44 9.54 42 218076 7510 110363671
Intraocular pressure increased 16.39 9.54 53 218065 10823 110360358
Intracranial hypotension 16.32 9.54 12 218106 626 110370555
Air embolism 16.29 9.54 12 218106 628 110370553
Device malfunction 16.26 9.54 96 218022 25462 110345719
Postpartum disorder 16.23 9.54 4 218114 9 110371172
Kidney infection 16.18 9.54 96 218022 25503 110345678
Product administered at inappropriate site 16.15 9.54 34 218084 5359 110365822
Medical device site abscess 16.10 9.54 8 218110 202 110370979
Upper-airway cough syndrome 16.09 9.54 68 218050 15789 110355392
Injection site joint infection 16.06 9.54 6 218112 73 110371108
Myelodysplastic syndrome 15.99 9.54 31 218087 37453 110333728
Vitamin B12 increased 15.98 9.54 20 218098 2035 110369146
Adverse reaction 15.91 9.54 21 218097 29573 110341608
Tenderness 15.87 9.54 106 218012 29331 110341850
Parophthalmia 15.82 9.54 11 218107 525 110370656
Hepatic function abnormal 15.81 9.54 107 218011 89188 110281993
Aspartate aminotransferase 15.79 9.54 14 218104 955 110370226
Gastroenteritis 15.77 9.54 33 218085 38767 110332414
Blood uric acid increased 15.77 9.54 84 218034 21445 110349736
Allodynia 15.76 9.54 20 218098 2063 110369118
Postural orthostatic tachycardia syndrome 15.74 9.54 19 218099 1863 110369318
Foetal heart rate abnormal 15.72 9.54 12 218106 663 110370518
Injection site scar 15.72 9.54 15 218103 1125 110370056
Tooth demineralisation 15.69 9.54 3 218115 0 110371181
Application site pallor 15.69 9.54 3 218115 0 110371181
Dental restoration failure 15.64 9.54 15 218103 1132 110370049
Ventricular asystole 15.54 9.54 10 218108 419 110370762
Proteinuria 15.47 9.54 35 218083 39983 110331198
Muscle strain 15.47 9.54 53 218065 11149 110360032
Vitamin D deficiency 15.42 9.54 75 218043 18477 110352704
Restrictive pulmonary disease 15.39 9.54 25 218093 3234 110367947
Eye pruritus 15.32 9.54 114 218004 32661 110338520
Nephropathy toxic 15.28 9.54 19 218099 27459 110343722
Vitamin D increased 15.26 9.54 13 218105 840 110370341
Product administration interrupted 15.22 9.54 53 218065 11239 110359942
Epinephrine increased 15.16 9.54 4 218114 13 110371168
Colitis 15.09 9.54 129 217989 102194 110268987
Depressed level of consciousness 15.08 9.54 308 217810 111970 110259211
Injection site necrosis 15.05 9.54 18 218100 1748 110369433
Brain herniation 15.03 9.54 45 218073 8818 110362363
Myoclonus 14.99 9.54 114 218004 32884 110338297
Panniculitis 14.93 9.54 6 218112 15576 110355605
Anion gap increased 14.93 9.54 29 218089 4315 110366866
Brugada syndrome 14.89 9.54 17 218101 1571 110369610
Inflammatory marker increased 14.83 9.54 5 218113 14464 110356717
Corneal abrasion 14.79 9.54 16 218102 1393 110369788
Poor quality product administered 14.77 9.54 30 218088 4611 110366570
Atonic urinary bladder 14.77 9.54 7 218111 159 110371022
Economic problem 14.71 9.54 28 218090 4103 110367078
Post cardiac arrest syndrome 14.63 9.54 5 218113 46 110371135
Tachypnoea 14.62 9.54 130 217988 39265 110331916
Maternal exposure timing unspecified 14.57 9.54 12 218106 21001 110350180
Device expulsion 14.57 9.54 24 218094 30867 110340314
Postresuscitation encephalopathy 14.54 9.54 5 218113 47 110371134
Live birth 14.54 9.54 79 218039 69405 110301776
Cholangitis 14.53 9.54 7 218111 16328 110354853
Pharyngitis 14.53 9.54 92 218026 25006 110346175
Arrhythmia 14.52 9.54 205 217913 69370 110301811
Transaminases increased 14.43 9.54 70 218048 63320 110307861
Skin test positive 14.42 9.54 16 218102 1433 110369748
Exophthalmos 14.39 9.54 20 218098 2253 110368928
Immune reconstitution inflammatory syndrome 14.37 9.54 7 218111 16219 110354962
Blood immunoglobulin E 14.35 9.54 5 218113 49 110371132
Post-anoxic myoclonus 14.35 9.54 5 218113 49 110371132
Injection site oedema 14.35 9.54 18 218100 1836 110369345
Rheumatoid factor increased 14.33 9.54 21 218097 2484 110368697
Speech disorder 14.33 9.54 185 217933 61384 110309797
Vascular resistance systemic decreased 14.32 9.54 8 218110 258 110370923
Macroglossia 14.31 9.54 16 218102 1445 110369736
Second primary malignancy 14.25 9.54 9 218109 18059 110353122
Reversible cerebral vasoconstriction syndrome 14.24 9.54 30 218088 4731 110366450
Dehydration 14.23 9.54 431 217687 279080 110092101
Psychotic disorder 14.23 9.54 52 218066 50885 110320296
Palmar-plantar erythrodysaesthesia syndrome 14.20 9.54 38 218080 40987 110330194
Immunodeficiency 14.19 9.54 35 218083 38803 110332378
Painful ejaculation 14.19 9.54 6 218112 103 110371078
Anaesthetic complication cardiac 14.19 9.54 6 218112 103 110371078
Treatment noncompliance 14.18 9.54 85 218033 72905 110298276
Full blood count decreased 14.17 9.54 26 218092 32073 110339108
Suicide attempt 14.09 9.54 133 217985 103261 110267920
Foetal death 14.09 9.54 7 218111 16038 110355143
Cardiac failure 14.04 9.54 273 217845 187353 110183828
Vaginal discharge 14.02 9.54 9 218109 17899 110353282
Product prescribing error 13.94 9.54 53 218065 51278 110319903
Blindness cortical 13.90 9.54 14 218104 1121 110370060
Mucosal inflammation 13.83 9.54 122 217996 96019 110275162
Immunisation reaction 13.81 9.54 12 218106 797 110370384
Brain death 13.73 9.54 36 218082 6537 110364644
Foreign body in respiratory tract 13.68 9.54 9 218109 392 110370789
Vomiting 13.67 9.54 1580 216538 909095 109462086
Removal of foreign body from throat 13.62 9.54 3 218115 3 110371178
Lacrimation increased 13.55 9.54 106 218012 30844 110340337
Temperature intolerance 13.52 9.54 59 218059 13891 110357290
Bradyarrhythmia 13.51 9.54 30 218088 4904 110366277
Hepatitis C 13.50 9.54 4 218114 12569 110358612
Basal cell carcinoma 13.46 9.54 45 218073 45225 110325956
Prostatic pain 13.45 9.54 8 218110 291 110370890
Enzyme induction 13.40 9.54 6 218112 119 110371062
Oxygen therapy 13.40 9.54 27 218091 4126 110367055
Granulocyte count increased 13.39 9.54 18 218100 1965 110369216
Anion gap 13.38 9.54 18 218100 1967 110369214
Platelet count decreased 13.35 9.54 349 217769 230094 110141087
Acidosis 13.30 9.54 83 218035 22448 110348733
Cardiopulmonary failure 13.29 9.54 40 218078 7863 110363318
Nightmare 13.28 9.54 126 217992 38737 110332444
Central venous catheter removal 13.25 9.54 10 218108 543 110370638
Amaurosis 13.22 9.54 16 218102 1573 110369608
Uveitis 13.17 9.54 14 218104 21696 110349485
Procedural anxiety 13.16 9.54 12 218106 849 110370332
Corneal striae 13.16 9.54 5 218113 64 110371117
ECG signs of myocardial ischaemia 13.14 9.54 9 218109 419 110370762
Product prescribing issue 13.14 9.54 55 218063 12717 110358464
Myopathy 13.12 9.54 18 218100 24942 110346239
Catheter site haemorrhage 13.11 9.54 33 218085 5847 110365334
Mouth swelling 13.11 9.54 38 218080 7316 110363865
Respiratory syncytial virus infection 13.10 9.54 60 218058 14424 110356757
Colitis microscopic 13.10 9.54 5 218113 13389 110357792
Mania 13.08 9.54 13 218105 20783 110350398
Administration related reaction 13.07 9.54 8 218110 307 110370874
Cognitive disorder 13.05 9.54 110 218008 87401 110283780
Caffeine allergy 13.05 9.54 4 218114 25 110371156
Vaccination complication 13.00 9.54 12 218106 863 110370318
Nervous system disorder 12.99 9.54 107 218011 31614 110339567
Therapeutic product effect prolonged 12.97 9.54 11 218107 707 110370474
Tongue pruritus 12.96 9.54 12 218106 866 110370315
Congenital anomaly 12.94 9.54 13 218105 1038 110370143
Injection site ulcer 12.94 9.54 12 218106 868 110370313
Infusion site infection 12.93 9.54 19 218099 2253 110368928
Anoxia 12.85 9.54 9 218109 435 110370746
Device issue 12.83 9.54 114 218004 34421 110336760
Respiratory rate decreased 12.80 9.54 34 218084 6224 110364957
Cardiac output decreased 12.80 9.54 18 218100 2051 110369130
Aplastic anaemia 12.79 9.54 87 218031 24221 110346960
Personality change 12.76 9.54 3 218115 10999 110360182
Acute respiratory failure 12.73 9.54 214 217904 75046 110296135
Graft versus host disease 12.72 9.54 11 218107 18795 110352386
Glycogen storage disease type II 12.66 9.54 4 218114 28 110371153
Bronchopulmonary aspergillosis allergic 12.65 9.54 41 218077 8385 110362796
Neutropenic sepsis 12.63 9.54 26 218092 30720 110340461
Proctitis 12.59 9.54 9 218109 16918 110354263
Atrophy of globe 12.56 9.54 5 218113 73 110371108
Perfume sensitivity 12.53 9.54 13 218105 1078 110370103
Implant site bruising 12.53 9.54 8 218110 331 110370850
Meningitis 12.52 9.54 51 218067 11651 110359530
Injection site discolouration 12.51 9.54 43 218075 9060 110362121
Metastases to bone 12.49 9.54 27 218091 31345 110339836
Post lumbar puncture syndrome 12.48 9.54 13 218105 1084 110370097
Pancreatitis 12.46 9.54 121 217997 93412 110277769
Enterobacter pneumonia 12.45 9.54 10 218108 595 110370586
Oral pruritus 12.44 9.54 23 218095 3297 110367884
Brown-Sequard syndrome 12.44 9.54 5 218113 75 110371106
Diffuse large B-cell lymphoma 12.43 9.54 8 218110 15890 110355291
Hypoaesthesia 12.43 9.54 500 217618 313723 110057458
Therapy non-responder 12.41 9.54 402 217716 156905 110214276
Tryptase 12.41 9.54 3 218115 6 110371175
Nerve root injury cervical 12.41 9.54 3 218115 6 110371175
Product availability issue 12.39 9.54 39 218079 7851 110363330
Histamine level increased 12.39 9.54 6 218112 143 110371038
Urticaria chronic 12.32 9.54 11 218107 757 110370424
Sleep disorder due to a general medical condition 12.30 9.54 157 217961 51955 110319226
Ocular hyperaemia 12.27 9.54 125 217993 39161 110332020
Product contamination 12.24 9.54 17 218101 1914 110369267
Eosinophilic oesophagitis 12.22 9.54 14 218104 1298 110369883
Spinal cord ischaemia 12.22 9.54 7 218111 237 110370944
Incision site swelling 12.21 9.54 8 218110 346 110370835
Autoimmune hepatitis 12.20 9.54 7 218111 14797 110356384
Administration site rash 12.20 9.54 4 218114 32 110371149
Temperature regulation disorder 12.19 9.54 5 218113 12821 110358360
Vascular stent thrombosis 12.19 9.54 26 218092 4135 110367046
Drug abuse 12.12 9.54 262 217856 177149 110194032
Complex regional pain syndrome 12.11 9.54 19 218099 2386 110368795
Erythema of eyelid 12.09 9.54 25 218093 3890 110367291
Injection site joint swelling 12.09 9.54 4 218114 33 110371148
Hypophosphataemia 12.05 9.54 109 218009 33073 110338108
Cutaneous vasculitis 12.04 9.54 5 218113 12724 110358457
Local reaction 12.03 9.54 11 218107 781 110370400
Eye infection intraocular 11.98 9.54 4 218114 34 110371147
Peritonitis bacterial 11.97 9.54 3 218115 10530 110360651
Irregular breathing 11.95 9.54 10 218108 631 110370550
Hyperkalaemia 11.94 9.54 192 217926 135604 110235577
Cranial nerve palsies multiple 11.89 9.54 7 218111 250 110370931
Masked fever 11.88 9.54 4 218114 35 110371146
Conjunctival oedema 11.87 9.54 15 218103 1541 110369640
Eclampsia 11.85 9.54 8 218110 364 110370817
Cold urticaria 11.83 9.54 7 218111 252 110370929
Headache 11.80 9.54 1946 216172 880431 109490750
Drug eruption 11.79 9.54 60 218058 53599 110317582
Oesophageal carcinoma 11.78 9.54 4 218114 11520 110359661
Sensorimotor disorder 11.76 9.54 13 218105 1159 110370022
Tidal volume decreased 11.76 9.54 5 218113 87 110371094
Obstructive airways disorder 11.74 9.54 141 217977 46008 110325173
Application site alopecia 11.69 9.54 4 218114 37 110371144
Thrombotic microangiopathy 11.68 9.54 25 218093 29124 110342057
Nail bed tenderness 11.62 9.54 8 218110 376 110370805
Joint noise 11.61 9.54 29 218089 5114 110366067
Incision site rash 11.59 9.54 4 218114 38 110371143
Splenomegaly 11.59 9.54 19 218099 24479 110346702
Troponin T increased 11.58 9.54 26 218092 4280 110366901
Hallucination 11.58 9.54 136 217982 101296 110269885
Quality of life decreased 11.58 9.54 57 218061 14112 110357069
Vitreous floaters 11.57 9.54 42 218076 9092 110362089
CSF pressure increased 11.54 9.54 7 218111 264 110370917
Thyrotoxic crisis 11.52 9.54 17 218101 2023 110369158
Uterine atony 11.52 9.54 7 218111 265 110370916
Obstruction 11.51 9.54 31 218087 5721 110365460
Vitreous disorder 11.49 9.54 8 218110 383 110370798
Long QT syndrome congenital 11.48 9.54 6 218112 169 110371012
No reaction on previous exposure to drug 11.47 9.54 7 218111 267 110370914
Retinal haemorrhage 11.46 9.54 43 218075 9458 110361723
Heart rate decreased 11.44 9.54 228 217890 82528 110288653
Agitation 11.42 9.54 298 217820 112753 110258428
Extubation 11.41 9.54 4 218114 40 110371141
Reaction to excipient 11.40 9.54 17 218101 2042 110369139
Fall 11.37 9.54 1030 217088 602452 109768729
Periorbital oedema 11.37 9.54 45 218073 10147 110361034
Angina pectoris 11.35 9.54 74 218044 62221 110308960
Concussion 11.34 9.54 49 218069 11489 110359692
Tachyarrhythmia 11.33 9.54 39 218079 8222 110362959
Catecholamine crisis 11.31 9.54 5 218113 96 110371085
XIIth nerve injury 11.31 9.54 3 218115 10 110371171
Tuberculosis 11.31 9.54 11 218107 17763 110353418
Pupillary light reflex tests abnormal 11.30 9.54 8 218110 393 110370788
Normal newborn 11.30 9.54 78 218040 21818 110349363
Electrocardiogram P wave abnormal 11.29 9.54 8 218110 394 110370787
Injection site nerve damage 11.27 9.54 5 218113 97 110371084
Acute myeloid leukaemia 11.25 9.54 38 218080 38072 110333109
Cholelithiasis 11.22 9.54 76 218042 63346 110307835
Azotaemia 11.22 9.54 3 218115 10082 110361099
Ocular retrobulbar haemorrhage 11.17 9.54 6 218112 179 110371002
Hallucination, auditory 11.11 9.54 22 218096 26375 110344806
Renal failure 11.10 9.54 550 217568 226024 110145157
Hypercatabolism 11.09 9.54 3 218115 11 110371170
Myocardial necrosis marker increased 11.09 9.54 24 218094 3856 110367325
Spinal cord injury 11.07 9.54 15 218103 1650 110369531
Muscle tension dysphonia 11.06 9.54 7 218111 285 110370896
Accidental death 11.05 9.54 28 218090 4981 110366200
Poisoning deliberate 11.04 9.54 22 218096 26309 110344872
Eosinophilia 10.98 9.54 68 218050 57868 110313313
Renal cancer 10.98 9.54 6 218112 13028 110358153
Cholestasis of pregnancy 10.95 9.54 13 218105 1252 110369929
Hypertonia 10.94 9.54 39 218079 8367 110362814
Anal skin tags 10.92 9.54 9 218109 556 110370625
Eyelid contusion 10.91 9.54 5 218113 105 110371076
Coma scale abnormal 10.89 9.54 43 218075 9683 110361498
Depression 10.88 9.54 513 217605 316822 110054359
Infusion site oedema 10.87 9.54 14 218104 1466 110369715
Hypoproteinaemia 10.87 9.54 31 218087 5914 110365267
Thrombosis 10.85 9.54 286 217832 108376 110262805
Blindness transient 10.83 9.54 31 218087 5925 110365256
Brain hypoxia 10.81 9.54 13 218105 1269 110369912
Tooth infection 10.80 9.54 78 218040 22138 110349043
Arthritis infective 10.80 9.54 45 218073 10384 110360797
Conjunctivitis 10.78 9.54 108 218010 33684 110337497
Optic nerve injury 10.76 9.54 10 218108 725 110370456
Nephrotic syndrome 10.76 9.54 7 218111 13824 110357357
Drug-disease interaction 10.74 9.54 16 218102 1920 110369261
Infusion site scar 10.70 9.54 8 218110 428 110370753
Hepatic encephalopathy 10.69 9.54 25 218093 28231 110342950
Serotonin syndrome 10.67 9.54 170 217948 58983 110312198
Sensitive skin 10.65 9.54 23 218095 3689 110367492
Nodal arrhythmia 10.65 9.54 17 218101 2167 110369014
Product contamination physical 10.62 9.54 7 218111 306 110370875
Reperfusion arrhythmia 10.60 9.54 7 218111 307 110370874
Chronic obstructive pulmonary disease 10.53 9.54 286 217832 108872 110262309
Postictal state 10.53 9.54 18 218100 2428 110368753
Lymphocyte count decreased 10.51 9.54 165 217953 57078 110314103
Neurogenic shock 10.50 9.54 11 218107 923 110370258
Respiratory tract oedema 10.49 9.54 12 218106 1111 110370070
Hand-foot-and-mouth disease 10.48 9.54 10 218108 750 110370431
Bradyphrenia 10.47 9.54 5 218113 11723 110359458
Immunosuppressant drug level increased 10.47 9.54 5 218113 11719 110359462
Tenosynovitis 10.45 9.54 10 218108 16273 110354908
Eosinophilic granulomatosis with polyangiitis 10.43 9.54 4 218114 10682 110360499
Throat clearing 10.38 9.54 25 218093 4308 110366873
Haematuria 10.38 9.54 109 218009 82896 110288285
Vitreous haemorrhage 10.37 9.54 26 218092 4594 110366587
Coronary artery thrombosis 10.36 9.54 21 218097 3223 110367958
Cytopenia 10.34 9.54 28 218090 30088 110341093
Mucormycosis 10.34 9.54 4 218114 10624 110360557
Extrasystoles 10.33 9.54 38 218080 8280 110362901
Hypothyroidism 10.27 9.54 93 218025 72806 110298375
Alanine aminotransferase increased 10.20 9.54 280 217838 183493 110187688
Opisthotonus 10.19 9.54 10 218108 776 110370405
Balance disorder 10.18 9.54 165 217953 116395 110254786
Product measured potency issue 10.17 9.54 6 218112 215 110370966
Physical product label issue 10.14 9.54 4 218114 57 110371124
Respiratory tract infection viral 10.12 9.54 30 218088 5848 110365333
Macular degeneration 10.06 9.54 17 218101 21642 110349539
Hypogammaglobulinaemia 10.04 9.54 15 218103 20061 110351120
Multiple sclerosis relapse 10.03 9.54 58 218060 50182 110320999
Oxygen saturation abnormal 10.01 9.54 29 218089 5582 110365599
Infusion site vesicles 10.00 9.54 9 218109 626 110370555
Injury corneal 10.00 9.54 6 218112 222 110370959
Hepatic failure 9.99 9.54 87 218031 68652 110302529
Allergy to arthropod sting 9.98 9.54 7 218111 339 110370842
Infusion site inflammation 9.95 9.54 8 218110 477 110370704
Cold sweat 9.94 9.54 76 218042 21955 110349226
Genital erosion 9.93 9.54 10 218108 801 110370380
Upper gastrointestinal haemorrhage 9.91 9.54 58 218060 50038 110321143
Metastases to lung 9.90 9.54 19 218099 23044 110348137
Repetitive strain injury 9.90 9.54 6 218112 226 110370955
Cardiac assistance device user 9.90 9.54 5 218113 131 110371050
pH body fluid abnormal 9.90 9.54 5 218113 131 110371050
Skin laceration 9.88 9.54 106 218012 33647 110337534
Atrioventricular block 9.85 9.54 62 218056 16815 110354366
Electrocardiogram QRS complex shortened 9.84 9.54 10 218108 810 110370371
Vaginal abscess 9.83 9.54 8 218110 485 110370696
Oxidative stress 9.83 9.54 4 218114 62 110371119
Diplopia 9.80 9.54 126 217992 41768 110329413
Scratch 9.75 9.54 51 218067 12928 110358253
Victim of spousal abuse 9.75 9.54 3 218115 19 110371162
Bacterial infection 9.75 9.54 136 217982 45900 110325281
Transient ischaemic attack 9.74 9.54 80 218038 63902 110307279
Electrocardiogram U wave present 9.72 9.54 5 218113 136 110371045
Product label issue 9.72 9.54 11 218107 1007 110370174
Post procedural haemorrhage 9.69 9.54 58 218060 15454 110355727
Acute hepatic failure 9.68 9.54 38 218080 36430 110334751
Sensory loss 9.67 9.54 74 218044 21383 110349798
Incision site pain 9.66 9.54 20 218098 3115 110368066
Anaphylactoid syndrome of pregnancy 9.66 9.54 4 218114 65 110371116
N-terminal prohormone brain natriuretic peptide 9.66 9.54 4 218114 65 110371116
Gaze palsy 9.65 9.54 21 218097 3386 110367795
Female genital tract fistula 9.64 9.54 11 218107 16508 110354673
Heliotrope rash 9.62 9.54 6 218112 238 110370943
Cardiac procedure complication 9.61 9.54 7 218111 360 110370821
Colorectal cancer 9.61 9.54 3 218115 9111 110362070
Brachial plexus injury 9.59 9.54 5 218113 140 110371041
Gastrointestinal toxicity 9.58 9.54 5 218113 11143 110360038
Ejection fraction decreased 9.58 9.54 123 217995 40757 110330424
Lip disorder 9.57 9.54 14 218104 1653 110369528
Skin irritation 9.56 9.54 60 218058 16259 110354922

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 49.30 34.78 36 241 1597 112079

Pharmacologic Action:

SourceCodeDescription
ATC A01AD01 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Other agents for local oral treatment
ATC B02BC09 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
VITAMIN K AND OTHER HEMOSTATICS
Local hemostatics
ATC C01CA24 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
ATC R01AA14 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
ATC R03AA01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Alpha- and beta-adrenoreceptor agonists
ATC R03AK01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC S01EA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Sympathomimetics in glaucoma therapy
ATC S01EA51 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Sympathomimetics in glaucoma therapy
FDA CS M0003647 Catecholamines
FDA MoA N0000000209 Adrenergic alpha-Agonists
FDA MoA N0000000245 Adrenergic beta-Agonists
FDA EPC N0000175552 alpha-Adrenergic Agonist
FDA EPC N0000175555 beta-Adrenergic Agonist
FDA EPC N0000175570 Catecholamine
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D009184 Mydriatics
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:24621 hormones
CHEBI has role CHEBI:35522 beta-adrenergic agonists
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:37886 adrenergic agonists
CHEBI has role CHEBI:50513 mydriatics
CHEBI has role CHEBI:75771 Mus musculus metabolites

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S01EA Sympathomimetics in glaucoma therapy 5 drugs
apraclonidinebrimonidineclonidinedipivefrineripasudil

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchiectasis indication 12295008 DOID:9563
Bronchitis indication 32398004 DOID:6132
Anaphylaxis indication 39579001
Local anesthesia, by infiltration indication 44596000
Low blood pressure indication 45007003
Wheezing indication 56018004
Hypotension associated with septic shock indication 76571007
Open-angle glaucoma indication 84494001 DOID:1067
Pulmonary emphysema indication 87433001
Dyspnea indication 267036007
Exacerbation of asthma indication 281239006
Asthma management indication 406162001
Acute exacerbation of asthma indication 708038006
Administration of Local Anesthetic Nerve Block indication
Allergic Reactions indication
Ventricular fibrillation off-label use 71908006
Asthma off-label use 195967001 DOID:2841
Local anesthesia off-label use 386761002
Cardiac arrest off-label use 410429000 DOID:0060319
Keratitis contraindication 5888003 DOID:4677
Bacterial septicemia contraindication 10001005 DOID:0040085
Sinus tachycardia contraindication 11092001
Myocardial infarction contraindication 22298006 DOID:5844
Aphakia contraindication 24010005
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Hypovolemia contraindication 28560003
Hypercapnia contraindication 29596007
Parkinsonism contraindication 32798002
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Stokes-Adams syndrome contraindication 46935006
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Atrial fibrillation contraindication 49436004 DOID:0060224
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Sinus bradycardia contraindication 49710005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Iritis contraindication 65074000 DOID:1406
Cerebral arteriosclerosis contraindication 65312002
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Decreased respiratory function contraindication 80954004
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Angina pectoris contraindication 194828000
Primary dilated cardiomyopathy contraindication 195021004
Partial atrioventricular block contraindication 195039008
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Sepsis syndrome contraindication 238150007
Benign prostatic hyperplasia contraindication 266569009
Psychoneurotic personality disorder contraindication 268634009
Deficiency of cholinesterase contraindication 360607009
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Peripheral vascular disease contraindication 400047006
Anterior uveitis contraindication 410692006 DOID:1407
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Thrombosis contraindication 439127006
Pupillary Block Glaucoma contraindication
Occlusive Vascular Disease contraindication
Lidocaine Toxicity contraindication
Regional Anesthesia for Labor Pain contraindication
Reduced Hepatic Blood Flow contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.97 acidic
pKa2 12.82 acidic
pKa3 13.64 acidic
pKa4 8.71 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 1MG BASE/ML (EQ 1MG BASE/ML) ADRENALIN PH HEALTH N204200 Dec. 7, 2012 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS 9295657 March 13, 2035 EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
EQ 30MG BASE/30ML (EQ 1MG BASE/ML) ADRENALIN PH HEALTH N204640 Dec. 18, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS 9295657 March 13, 2035 EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
0.15MG/0.3ML (0.15MG/0.3ML) SYMJEPI ADAMIS PHARMS CORP N207534 Sept. 27, 2018 DISCN SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 11141540 Oct. 20, 2036 A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE
0.3MG/0.3ML (0.3MG/0.3ML) SYMJEPI ADAMIS PHARMS CORP N207534 June 15, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 11141540 Oct. 20, 2036 A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE
EQ 0.15MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10688244 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.15MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10842938 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.15MG/DELIVERY AUVI-Q KALEO INC N201739 Aug. 10, 2012 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 11771830 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10688244 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 10842938 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
EQ 0.1MG/DELIVERY AUVI-Q KALEO INC N201739 Nov. 17, 2017 RX SOLUTION INTRAMUSCULAR, SUBCUTANEOUS 11771830 Dec. 21, 2037 METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR
1MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 March 5, 2025 RX SPRAY NASAL 11173209 Feb. 6, 2038 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
2MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 Aug. 9, 2024 RX SPRAY NASAL 11173209 Feb. 6, 2038 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
1MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 March 5, 2025 RX SPRAY NASAL 10682414 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
1MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 March 5, 2025 RX SPRAY NASAL 11191838 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
1MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 March 5, 2025 RX SPRAY NASAL 11717571 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
1MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 March 5, 2025 RX SPRAY NASAL 11744895 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
1MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 March 5, 2025 RX SPRAY NASAL 11918655 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
2MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 Aug. 9, 2024 RX SPRAY NASAL 10682414 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
2MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 Aug. 9, 2024 RX SPRAY NASAL 11191838 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
2MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 Aug. 9, 2024 RX SPRAY NASAL 11717571 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
2MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 Aug. 9, 2024 RX SPRAY NASAL 11744895 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
2MG/SPRAY NEFFY ARS PHARMS OPERATION N214697 Aug. 9, 2024 RX SPRAY NASAL 11918655 Feb. 6, 2039 NASAL ADMINISTRATION OF EPINEPHRINE FOR THE TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS
10MG/250ML (40MCG/ML) ADRENALIN PH HEALTH N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
2MG/250ML (8MCG/ML) ADRENALIN PH HEALTH N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
4MG/250ML (16MCG/ML) ADRENALIN PH HEALTH N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
5MG/250ML (20MCG/ML) ADRENALIN PH HEALTH N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK
8MG/250ML (32MCG/ML) ADRENALIN PH HEALTH N215875 April 21, 2023 RX SOLUTION INTRAVENOUS 11083698 March 21, 2039 TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Alpha-1B adrenergic receptor GPCR AGONIST Ki 6.50 IUPHAR CHEMBL
Beta-2 adrenergic receptor GPCR AGONIST Kd 6.20 CHEMBL CHEMBL
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5.70 CHEMBL CHEMBL
Alpha-2B adrenergic receptor GPCR AGONIST Ki 6.40 DRUG MATRIX CHEMBL
Alpha-2A adrenergic receptor GPCR AGONIST Ki 6.56 DRUG MATRIX CHEMBL
Alpha-2C adrenergic receptor GPCR AGONIST Ki 6.45 DRUG MATRIX CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 6.66 CHEMBL CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.40 PDSP
Beta-3 adrenergic receptor GPCR AGONIST EC50 6.50 IUPHAR
D(1A) dopamine receptor GPCR Kd 4.26 CHEMBL
D(2) dopamine receptor GPCR Ki 6.04 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.43 PDSP
Beta-3 adrenergic receptor GPCR AGONIST EC50 6.50 IUPHAR
Alpha-1A adrenergic receptor GPCR IC50 6.20 CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 6.30 IUPHAR
Mu-type opioid receptor GPCR Ki 5.40 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.96 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.18 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.14 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.52 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.89 CHEMBL
Adrenergic receptor beta GPCR IC50 4.54 CHEMBL
M18 aspartyl aminopeptidase Enzyme IC50 5.52 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.48 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.01 DRUG MATRIX

External reference:

IDSource
4018034 VUID
N0000146377 NUI
D00996 KEGG_DRUG
51-42-3 SECONDARY_CAS_RN
4018032 VANDF
4018033 VANDF
4018034 VANDF
C0014563 UMLSCUI
CHEBI:28918 CHEBI
CHEMBL679 ChEMBL_ID
DB00668 DRUGBANK_ID
CHEMBL1256958 ChEMBL_ID
D004837 MESH_DESCRIPTOR_UI
5816 PUBCHEM_CID
2142 INN_ID
YKH834O4BH UNII
203180 RXNORM
3451 MMSL
3500 MMSL
4663 MMSL
4664 MMSL
4665 MMSL
4667 MMSL
72412 MMSL
d00699 MMSL
001774 NDDF
001776 NDDF
006223 NDDF
126134000 SNOMEDCT_US
387362001 SNOMEDCT_US
50685004 SNOMEDCT_US
65502005 SNOMEDCT_US
ALE PDB_CHEM_ID
CHEMBL3183376 ChEMBL_ID
55-31-2 SECONDARY_CAS_RN
479 IUPHAR_LIGAND_ID
YKH834O4BH INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5985 INJECTION 0.15 mg INTRAMUSCULAR ANDA 24 sections
Epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5986 INJECTION 0.30 mg INTRAMUSCULAR ANDA 24 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1694 INJECTION 0.30 mg SUBCUTANEOUS NDA authorized generic 25 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1695 INJECTION 0.15 mg SUBCUTANEOUS NDA authorized generic 25 sections
Epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9476 INJECTION 1 mg INTRAMUSCULAR ANDA 25 sections
LIDOCAINE HCl and EPINEPHRINE HUMAN PRESCRIPTION DRUG LABEL 2 0264-9378 INJECTION 0.01 mg EPIDURAL ANDA 12 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0338-0006 INJECTION, SOLUTION 16 ug INTRAVENOUS NDA 24 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0338-0024 INJECTION, SOLUTION 64 ug INTRAVENOUS NDA 24 sections
epinephrine HUMAN PRESCRIPTION DRUG LABEL 1 0338-0024 INJECTION, SOLUTION 64 ug INTRAVENOUS NDA 24 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0262 INJECTION, SOLUTION 0.02 mg SUBMUCOSAL ANDA 23 sections
Marcaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0557 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL ANDA 19 sections
Marcaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0557 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL ANDA 19 sections
Zorcaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0830 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL NDA authorized generic 29 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-0898 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL ANDA 22 sections
Lignospan Standard HUMAN PRESCRIPTION DRUG LABEL 2 0362-1095 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL ANDA 23 sections
Lignospan Forte HUMAN PRESCRIPTION DRUG LABEL 2 0362-1096 INJECTION, SOLUTION 0.02 mg SUBMUCOSAL ANDA 23 sections
Flavalta HUMAN PRESCRIPTION DRUG LABEL 2 0362-1200 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL NDA 16 sections
Vivacaine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9011 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL ANDA 19 sections
Septocaine and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9048 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL NDA 29 sections
Septocaine and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0362-9049 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL NDA 29 sections
LIDOCAINE HUMAN PRESCRIPTION DRUG LABEL 2 0404-6500 INJECTION, SOLUTION 0.02 mg SUBMUCOSAL ANDA 23 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 2 0404-6512 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL ANDA 23 sections
Articaine Hydrochloride and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0404-6620 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL NDA authorized generic 29 sections
Articaine Hydrochloride and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0404-6625 INJECTION, SOLUTION 0.01 mg SUBMUCOSAL NDA authorized generic 29 sections
Lidocaine Hydrochloride and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0404-9788 INJECTION, SOLUTION 10 ug INFILTRATION ANDA 12 sections
Lidocaine Hydrochloride and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0404-9792 INJECTION, SOLUTION 10 ug INFILTRATION ANDA 12 sections
EPINEPHRINE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9806 INJECTION 0.10 mg INTRAVENOUS NDA 14 sections
EPINEPHRINE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9806 INJECTION 0.10 mg INTRAVENOUS NDA 14 sections
Adrenalin HUMAN PRESCRIPTION DRUG LABEL 1 0404-9810 INJECTION 1 mg INTRAMUSCULAR NDA 16 sections
Bupivacaine Hydrochloride and Epinephrine HUMAN PRESCRIPTION DRUG LABEL 2 0404-9828 INJECTION, SOLUTION 5 ug INFILTRATION ANDA 12 sections