alacepril indications/contra

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 101 74258-86-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alacepril
  • cetapril
  • DU-1219
  • cenapride
  • Molecular weight: 406.50
  • Formula: C20H26N2O5S
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 103.78
  • ALOGS: -3.57
  • ROTB: 9

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1988 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR DRUG LABEL SCIENTIFIC LITERATURE

External reference:

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IDSource
D01900 KEGG_DRUG
008152 NDDF
71992 PUBCHEM_CID
C046835 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2103775 ChEMBL_ID
X39TL7JDPF UNII
5458 INN_ID
DB01197 DRUGBANK_ID
CHEBI:31182 CHEBI

Pharmaceutical products:

None