alacepril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 101 74258-86-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alacepril
  • cetapril
  • DU-1219
  • cenapride
It is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. It used for the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics).
  • Molecular weight: 406.50
  • Formula: C20H26N2O5S
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 103.78
  • ALOGS: -3.57
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 6, 1981 FDA PAR PHARM

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000000181 Angiotensin-converting Enzyme Inhibitors
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
CHEBI has role CHEBI:35457 ACE inhibitor
CHEBI has role CHEBI:35674 antihypertensive drugs
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Essential hypertension indication 59621000 DOID:10825




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR DRUG LABEL SCIENTIFIC LITERATURE

External reference:

IDSource
D01900 KEGG_DRUG
1998 RXNORM
C0051050 UMLSCUI
CHEBI:31182 CHEBI
CHEBI:3380 CHEBI
CHEMBL2103775 ChEMBL_ID
C046835 MESH_SUPPLEMENTAL_RECORD_UI
71992 PUBCHEM_CID
5458 INN_ID
X39TL7JDPF UNII
29439004 SNOMEDCT_US
387160004 SNOMEDCT_US
C0006938 UMLSCUI
DB01197 DRUGBANK_ID
4017614 VANDF
4373 INN_ID
4347 MMSL
455 MMSL
d00006 MMSL
D002216 MESH_DESCRIPTOR_UI
44093 PUBCHEM_CID
000656 NDDF
008152 NDDF

Pharmaceutical products:

None