ajmaline indications/contra

Stem definitionDrug idCAS RN
antiarrhythmics, ajmaline derivatives 100 4360-12-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ajmaline hydrochloride
  • ajmaline HCl
  • aritmina
  • rauverid
  • ajmaline
  • (+)-Ajmaline
  • ajmalin
  • cardiorythmine
  • gilurytmal
  • raugalline
An alkaloid found in the root of RAUWOLFIA SERPENTINA, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.
  • Molecular weight: 326.44
  • Formula: C20H26N2O2
  • CLOGP: 2.17
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 46.94
  • ALOGS: -1.90
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.30 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C01BA05 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ia
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D061567 Voltage-Gated Sodium Channel Blockers

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.52 acidic
pKa2 7.56 Basic
pKa3 6.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX

External reference:

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IDSource
N0000166953 NUI
C0001888 UMLSCUI
D00199 KEGG_DRUG
140MW6WGAF UNII
4410-48-4 SECONDARY_CAS_RN
423 RXNORM
N0000166953 NDFRT
003818 NDDF
6100671 PUBCHEM_CID
DB01426 DRUGBANK_ID
CHEMBL2105617 ChEMBL_ID
D000404 MESH_DESCRIPTOR_UI
CHEBI:28462 CHEBI

Pharmaceutical products:

None